Exercise Increases Bone in SEIPIN Deficient Lipodystrophy, Despite Low Marrow Adiposity.
Adipose Tissue
/ diagnostic imaging
Animals
Body Weight
Bone Marrow
/ diagnostic imaging
Cancellous Bone
/ diagnostic imaging
Diaphyses
/ diagnostic imaging
Disease Models, Animal
Epididymis
/ metabolism
Femur
/ diagnostic imaging
GTP-Binding Protein gamma Subunits
/ genetics
Lipodystrophy
/ diagnostic imaging
Male
Mice
Mice, Knockout
Organ Size
Perilipin-1
/ genetics
Physical Conditioning, Animal
X-Ray Microtomography
BSCL2
SEIPIN
anabolism
bone
bone marrow adipose tissue (BMAT)
congenital lipodystrophy
endocrinology and metabolism
exercise
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2021
2021
Historique:
received:
27
09
2021
accepted:
20
12
2021
entrez:
11
2
2022
pubmed:
12
2
2022
medline:
3
3
2022
Statut:
epublish
Résumé
Exercise, typically beneficial for skeletal health, has not yet been studied in lipodystrophy, a condition characterized by paucity of white adipose tissue, with eventual diabetes, and steatosis. We applied a mouse model of global deficiency of Bscl2 (SEIPIN), required for lipid droplet formation. Male twelve-week-old B6 knockouts (KO) and wild type (WT) littermates were assigned six-weeks of voluntary, running exercise (E) versus non-exercise (N=5-8). KO weighed 14% less than WT (p=0.01) and exhibited an absence of epididymal adipose tissue; KO liver Plin1 via qPCR was 9-fold that of WT (p=0.04), consistent with steatosis. Bone marrow adipose tissue (BMAT), unlike white adipose, was measurable, although 40.5% lower in KO vs WT (p=0.0003) via 9.4T MRI/advanced image analysis. SEIPIN ablation's most notable effect marrow adiposity was in the proximal femoral diaphysis (-56% KO vs WT, p=0.005), with relative preservation in KO-distal-femur. Bone via μCT was preserved in SEIPIN KO, though some quality parameters were attenuated. Running distance, speed, and time were comparable in KO and WT. Exercise reduced weight (-24% WT-E vs WT p<0.001) but not in KO. Notably, exercise increased trabecular BV/TV in both (+31%, KO-E vs KO, p=0.004; +14%, WT-E vs WT, p=0.006). The presence and distribution of BMAT in SEIPIN KO, though lower than WT, is unexpected and points to a uniqueness of this depot. That trabecular bone increases were achievable in both KO and WT, despite a difference in BMAT quantity/distribution, points to potential metabolic flexibility during exercise-induced skeletal anabolism.
Identifiants
pubmed: 35145475
doi: 10.3389/fendo.2021.782194
pmc: PMC8822583
doi:
Substances chimiques
Bscl2 protein, mouse
0
GTP-Binding Protein gamma Subunits
0
Perilipin-1
0
Plin1 protein, mouse
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
782194Subventions
Organisme : NIAMS NIH HHS
ID : R01 AR073264
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR075803
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK107481
Pays : United States
Organisme : NCATS NIH HHS
ID : KL2 TR002490
Pays : United States
Informations de copyright
Copyright © 2022 McGrath, Little-Letsinger, Sankaran, Sen, Xie, Styner, Zong, Chen, Rubin, Klett, Coleman and Styner.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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