Antimicrobial oxygen-loaded nanobubbles as promising tools to promote wound healing in hypoxic human keratinocytes.
Candida albicans
Chronic wounds (CWs)
Keratinocytes
Methicillin-resistant Staphylococcus aureus (MRSA)
Nanobubbles (NBs)
Journal
Toxicology reports
ISSN: 2214-7500
Titre abrégé: Toxicol Rep
Pays: Ireland
ID NLM: 101630272
Informations de publication
Date de publication:
2022
2022
Historique:
received:
15
09
2021
revised:
29
12
2021
accepted:
25
01
2022
entrez:
11
2
2022
pubmed:
12
2
2022
medline:
12
2
2022
Statut:
epublish
Résumé
Chronic wounds (CWs) are typically characterized by persistent hypoxia, exacerbated inflammation, and impaired skin tissue remodeling. Additionally, CWs are often worsened by microbial infections. Oxygen-loaded nanobubbles (OLNBs), displaying a peculiar structure based on oxygen-solving perfluorocarbons such as perfluoropentane in the inner core and polysaccharydes including chitosan in the outer shell, have proven effective in delivering oxygen to hypoxic tissues. Antimicrobial properties have been largely reported for chitosan. In the present work chitosan/perfluoropentane OLNBs were challenged for biocompatibility with human skin cells and ability to promote wound healing processes, as well as for their antimicrobial properties against methicillin-resistant
Identifiants
pubmed: 35145879
doi: 10.1016/j.toxrep.2022.01.005
pii: S2214-7500(22)00005-1
pmc: PMC8818485
doi:
Types de publication
Journal Article
Langues
eng
Pagination
154-162Informations de copyright
© 2022 The Authors. Published by Elsevier B.V.
Déclaration de conflit d'intérêts
The authors report no declarations of interest.
Références
Adv Colloid Interface Sci. 2000 Jul 28;86(3):153-93
pubmed: 10997763
Int J Pharm. 2009 Aug 13;378(1-2):215-7
pubmed: 19501639
Eur J Pharm Biopharm. 2009 Feb;71(2):257-63
pubmed: 18955137
Clin Infect Dis. 2005 Feb 15;40(4):562-73
pubmed: 15712079
Int J Pharm. 2020 Sep 25;587:119676
pubmed: 32738458
J Cell Biol. 1988 Mar;106(3):761-71
pubmed: 2450098
Nanoscale Res Lett. 2019 Jan 16;14(1):24
pubmed: 30649655
Int J Nanomedicine. 2012;7:3309-18
pubmed: 22802689
ACS Appl Mater Interfaces. 2015 Jan 21;7(2):1087-99
pubmed: 25522372
Pharm Sci Technol Today. 2000 Sep 1;3(9):318-326
pubmed: 10996573
Curr Drug Deliv. 2018;15(6):752-754
pubmed: 29046151
BMC Microbiol. 2016 Sep 21;16(1):220
pubmed: 27654924
Cardiovasc Res. 2006 Feb 15;69(3):562-73
pubmed: 16405877
Mar Drugs. 2021 Feb 15;19(2):
pubmed: 33672056
Mini Rev Med Chem. 2020;20(18):1867-1878
pubmed: 32767938
Molecules. 2021 Jun 17;26(12):
pubmed: 34204251
Thyroid. 2016 May;26(5):705-16
pubmed: 26906083
Toxicol Appl Pharmacol. 2015 Nov 1;288(3):330-8
pubmed: 26276311
Int J Biochem Cell Biol. 2008;40(6-7):1334-47
pubmed: 18083622
Nucleic Acid Ther. 2021 Jun;31(3):201-207
pubmed: 32679000
J Chin Med Assoc. 2018 Feb;81(2):94-101
pubmed: 29169897
Int J Food Microbiol. 2001 Dec 30;71(2-3):235-44
pubmed: 11789941
J Drug Target. 2007 May;15(4):269-78
pubmed: 17487695
Br J Dermatol. 2010 Aug;163(2):257-68
pubmed: 20394633
J Colloid Interface Sci. 2003 May 15;261(2):402-10
pubmed: 16256549
Biomed Res Int. 2013;2013:527549
pubmed: 23844364
Int J Food Microbiol. 2004 Sep 1;95(2):147-55
pubmed: 15282127
Future Microbiol. 2020 Sep;15:1227-1236
pubmed: 33026879
PLoS One. 2014 Mar 21;9(3):e92723
pubmed: 24658463
J Clin Microbiol. 2019 Jun 25;57(7):
pubmed: 31018982
Adv Drug Deliv Rev. 2010 Jan 31;62(1):28-41
pubmed: 19874862
J Clin Microbiol. 2000 Feb;38(2):918-22
pubmed: 10655417
Skin Pharmacol Physiol. 2010;23(3):117-23
pubmed: 20051712
World J Diabetes. 2011 Feb 15;2(2):24-32
pubmed: 21537457
Wound Repair Regen. 2011 Jan-Feb;19(1):1-9
pubmed: 21235682
Adv Wound Care (New Rochelle). 2015 Apr 1;4(4):225-234
pubmed: 25945285
J Nanobiotechnology. 2014 Feb 03;12:5
pubmed: 24491160
Skin Pharmacol Physiol. 2010;23(3):164-70
pubmed: 20110767
Mediators Inflamm. 2015;2015:964838
pubmed: 25878404
Int J Pharm. 2009 Nov 3;381(2):160-5
pubmed: 19616610
PLoS One. 2015 Mar 17;10(3):e0119769
pubmed: 25781463
Int J Pharm. 2017 May 15;523(1):176-188
pubmed: 28330735
J Microbiol. 2011 Apr;49(2):171-7
pubmed: 21538235
Microbiol Mol Biol Rev. 1998 Mar;62(1):130-80
pubmed: 9529890
J R Soc Interface. 2013 Feb 20;10(82):20120939
pubmed: 23427093
Mol Ther. 2010 Oct;18(10):1787-95
pubmed: 20628361
Colloids Surf B Biointerfaces. 2015 May 1;129:39-46
pubmed: 25819364
Pharm Res. 2018 Feb 26;35(4):75
pubmed: 29484487
Cancer Cell Int. 2021 Jun 24;21(1):318
pubmed: 34167552
Biosci Biotechnol Biochem. 2016;80(3):466-72
pubmed: 26523859
J Cell Biol. 2007 Apr 9;177(1):7-11
pubmed: 17420288
Adv Wound Care (New Rochelle). 2014 May 1;3(5):390-399
pubmed: 24804159
PLoS One. 2016 Dec 21;11(12):e0168553
pubmed: 28002459
Toxicol Appl Pharmacol. 2015 Aug 1;286(3):198-206
pubmed: 25937238
Future Microbiol. 2015;10(6):929-39
pubmed: 26059617
Appl Microbiol Biotechnol. 2019 Nov;103(21-22):8669-8676
pubmed: 31522283
J Invest Dermatol. 2001 Jan;116(1):50-6
pubmed: 11168797
J Burn Care Rehabil. 2005 Jul-Aug;26(4):306-19
pubmed: 16006837