Monocyte-Platelet Aggregates Triggered by CD31 Molecule in Non-ST Elevation Myocardial Infarction: Clinical Implications in Plaque Rupture.
CD31
acute coronary syndromes
monocyte-platelet aggregates
plaque rupture
precision medicine
thrombus burden
unstable plaque
Journal
Frontiers in cardiovascular medicine
ISSN: 2297-055X
Titre abrégé: Front Cardiovasc Med
Pays: Switzerland
ID NLM: 101653388
Informations de publication
Date de publication:
2021
2021
Historique:
received:
14
07
2021
accepted:
20
12
2021
entrez:
11
2
2022
pubmed:
12
2
2022
medline:
12
2
2022
Statut:
epublish
Résumé
Despite the recent innovations in cardiovascular care, atherothrombosis is still a major complication of acute coronary syndromes (ACS). We evaluated the involvement of the CD31 molecule in thrombotic risk through the formation of monocyte-platelet (Mo-Plt) aggregates in patients with ACS with no-ST-segment elevation myocardial infarction (NSTEMI) on top of dual anti-platelet therapy (DAPT). We enrolled 19 control (CTRL) subjects, 46 stable angina (SA), and 86 patients with NSTEMI, of which, 16 with Intact Fibrous Cap (IFC) and 19 with Ruptured Fibrous Cap (RFC) as assessed by the Optical Coherence Tomography (OCT). The expression of CD31 on monocytes and platelets was measured. Following the coronary angiography, 52 NSTEMIs were further stratified according to thrombus grade (TG) evaluation. Finally, a series of
Identifiants
pubmed: 35146002
doi: 10.3389/fcvm.2021.741221
pmc: PMC8821091
doi:
Types de publication
Journal Article
Langues
eng
Pagination
741221Informations de copyright
Copyright © 2022 Vinci, Pedicino, Bonanni, d'Aiello, Pisano, Ponzo, Severino, Ciampi, Canonico, Russo, Di Sario, Vergallo, Filomia, Montone, Flego, Stefanini, Piacentini, Conte, Cribari, Massetti, Crea and Liuzzo.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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