Nuclear lamins: Structure and function in mechanobiology.
Journal
APL bioengineering
ISSN: 2473-2877
Titre abrégé: APL Bioeng
Pays: United States
ID NLM: 101726398
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
received:
17
12
2021
accepted:
11
01
2022
entrez:
11
2
2022
pubmed:
12
2
2022
medline:
12
2
2022
Statut:
epublish
Résumé
Nuclear lamins are type V intermediate filament proteins that polymerize into complex filamentous meshworks at the nuclear periphery and in less structured forms throughout the nucleoplasm. Lamins interact with a wide range of nuclear proteins and are involved in numerous nuclear and cellular functions. Within the nucleus, they play roles in chromatin organization and gene regulation, nuclear shape, size, and mechanics, and the organization and anchorage of nuclear pore complexes. At the whole cell level, they are involved in the organization of the cytoskeleton, cell motility, and mechanotransduction. The expression of different lamin isoforms has been associated with developmental progression, differentiation, and tissue-specific functions. Mutations in lamins and their binding proteins result in over 15 distinct human diseases, referred to as laminopathies. The laminopathies include muscular (e.g., Emery-Dreifuss muscular dystrophy and dilated cardiomyopathy), neurological (e.g., microcephaly), and metabolic (e.g., familial partial lipodystrophy) disorders as well as premature aging diseases (e.g., Hutchinson-Gilford Progeria and Werner syndromes). How lamins contribute to the etiology of laminopathies is still unknown. In this review article, we summarize major recent findings on the structure, organization, and multiple functions of lamins in nuclear and more global cellular processes.
Identifiants
pubmed: 35146235
doi: 10.1063/5.0082656
pii: 5.0082656
pmc: PMC8810204
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
011503Subventions
Organisme : NEI NIH HHS
ID : K99 EY032547
Pays : United States
Organisme : NIGMS NIH HHS
ID : P01 GM096971
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM106023
Pays : United States
Informations de copyright
© 2022 Author(s).
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