Effects of the food colorant carmoisine on zebrafish embryos at a wide range of concentrations.
Carmoisine
Dyes
E122
Food additive
Metabolome
Journal
Archives of toxicology
ISSN: 1432-0738
Titre abrégé: Arch Toxicol
Pays: Germany
ID NLM: 0417615
Informations de publication
Date de publication:
04 2022
04 2022
Historique:
received:
28
12
2021
accepted:
27
01
2022
pubmed:
12
2
2022
medline:
12
4
2022
entrez:
11
2
2022
Statut:
ppublish
Résumé
Since the middle of the twentieth century, the use of dyes has become more common in every food group as well as in the pharmaceutical, textile and cosmetic industries. Azo dyes, including carmoisine, are the most important of the dye classes with the widest color range. In this study, the effects of carmoisine exposure on the embryonic development of zebrafish at a wide dose scale, including recommended and overexposure doses (from 4 to 2000 ppm), were investigated in detail. For this purpose, many morphological and physiological parameters were examined in zebrafish exposed to carmoisine at determined doses for 96 h, and the mechanisms of action of the changes in these parameters were tried to be clarified with the metabolite levels determined. The no observed effect concentration (NOEC) and median lethal concentration (LC
Identifiants
pubmed: 35146542
doi: 10.1007/s00204-022-03240-2
pii: 10.1007/s00204-022-03240-2
pmc: PMC8831007
doi:
Substances chimiques
Azo Compounds
0
Coloring Agents
0
Food Coloring Agents
0
Naphthalenesulfonates
0
azo rubin S
DR4641L47F
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1089-1099Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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