Investigating the phenotypic and genetic associations between personality traits and suicidal behavior across major mental health diagnoses.
Bipolar disorder
Major depression
Personality
Polygenic score
Schizophrenia
Suicidal behavior
Journal
European archives of psychiatry and clinical neuroscience
ISSN: 1433-8491
Titre abrégé: Eur Arch Psychiatry Clin Neurosci
Pays: Germany
ID NLM: 9103030
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
received:
12
10
2021
accepted:
24
11
2021
pubmed:
12
2
2022
medline:
16
11
2022
entrez:
11
2
2022
Statut:
ppublish
Résumé
Personality traits influence risk for suicidal behavior. We examined phenotype- and genotype-level associations between the Big Five personality traits and suicidal ideation and attempt in major depressive, bipolar and schizoaffective disorder, and schizophrenia patients (N = 3012) using fixed- and random-effects inverse variance-weighted meta-analyses. Suicidal ideations were more likely to be reported by patients with higher neuroticism and lower extraversion phenotypic scores, but showed no significant association with polygenic load for these personality traits. Our findings provide new insights into the association between personality and suicidal behavior across mental illnesses and suggest that the genetic component of personality traits is unlikely to have strong causal effects on suicidal behavior.
Identifiants
pubmed: 35146571
doi: 10.1007/s00406-021-01366-5
pii: 10.1007/s00406-021-01366-5
pmc: PMC9653330
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1611-1620Subventions
Organisme : See Supplementary Material for a detailed list of funding sources
ID : See Supplementary Material for a detailed list of funding sources
Investigateurs
Bernhard T Baune
(BT)
Jan Fullerton
(J)
Philip B Mitchell
(PB)
Peter R Schofield
(PR)
Naomi R Wray
(NR)
Adam Wright
(A)
Susanne A Bengesser
(SA)
Eva Reininghaus
(E)
Claudio E M Banzato
(CEM)
Clarissa Dantas
(C)
Martin Alda
(M)
Cristiana Cruceanu
(C)
Julie Garnham
(J)
Paul Grof
(P)
Glenda MacQueen
(G)
Guy Rouleau
(G)
Claire Slaney
(C)
Gustavo Turecki
(G)
L Trevor Young
(LT)
Carlos A López Jaramillo
(CAL)
Tomás Novák
(T)
Pavla Stopkova
(P)
Clara Brichant-Petitjean
(C)
Mazda Adli
(M)
Sébastien Gard
(S)
Bruno Etain
(B)
Stéphane Jamain
(S)
Jean-Pierre Kahn
(JP)
Marion Leboyer
(M)
Mazda Adli
(M)
Michael Bauer
(M)
Sven Cichon
(S)
Franziska Degenhardt
(F)
Peter Falkai
(P)
Oliver Gruber
(O)
Urs Heilbronner
(U)
Per Hoffmann
(P)
Sarah Kittel-Schneider
(S)
Markus Nöthen
(M)
Andrea Pfennig
(A)
Daniela Reich-Erkelenz
(D)
Andreas Reif
(A)
Marcella Rietschel
(M)
Thomas G Schulze
(TG)
Florian Seemüller
(F)
Thomas Stamm
(T)
Raffaella Ardau
(R)
Caterina Chillotti
(C)
Maria Del Zompo
(M)
Mario Maj
(M)
Mirko Manchia
(M)
Palmiero Monteleone
(P)
Giovanni Severino
(G)
Alessio Squassina
(A)
Alfonso Tortorella
(A)
Kazufumi Akiyama
(K)
Kazufumi Akiyama
(K)
Ryota Hashimoto
(R)
Tadafumi Kato
(T)
Ichiro Kusumi
(I)
Takuya Masui Takuya Masui
(TMT)
Norio Ozaki
(N)
Piotr Czerski
(P)
Joanna Hauser
(J)
Sebastian Kliwicki
(S)
Janusz K Rybakowski
(JK)
Maria Grigoroiu-Serbanescu
(M)
Alexandru Obregia
(A)
Bárbara Arias
(B)
Antonio Benabarre
(A)
Francesc Colom
(F)
Esther Jiménez
(E)
Marina Mitjans
(M)
Eduard Vieta
(E)
Lena Backlund
(L)
Lena Backlund
(L)
Louise Frisén
(L)
Catharina Lavebratt
(C)
Lina Martinsson
(L)
Urban Ösby
(U)
Martin Schalling
(M)
Jean-Michel Aubry
(JM)
Sven Cichon
(S)
Alexandre Dayer
(A)
Per Hoffmann
(P)
Audrey Nallet
(A)
Hsi-Chung Chen
(HC)
David Cousins
(D)
Nirmala Akula
(N)
Joanna M Biernacka
(JM)
Joanna M Biernacka
(JM)
Elise T Bui
(ET)
J Ray DePaulo
(JR)
Sevilla D Detera-Wadleigh
(SD)
Mark A Frye
(MA)
Fernando S Goes
(FS)
Rebecca Hoban
(R)
Liping Hou
(L)
Layla Kassem
(L)
John R Kelsoe
(JR)
John R Kelsoe
(JR)
Gonzalo Laje
(G)
Gonzalo Laje
(G)
Susan G Leckband
(SG)
Michael J McCarthy
(MJ)
Francis J McMahon
(FJ)
Roy H Perlis
(RH)
James B Potash
(JB)
Thomas G Schulze
(TG)
Barbara Schweizer
(B)
Lisa R Seymour
(LR)
Jordan W Smoller
(JW)
Jo Steele
(J)
Sarah Tighe
(S)
Peter P Zandi
(PP)
Eva Reininghaus
(E)
Claudio E M Banzato
(CEM)
Clarissa Dantas
(C)
Martin Alda
(M)
Cristiana Cruceanu
(C)
Julie Garnham
(J)
Paul Grof
(P)
Glenda MacQueen
(G)
Guy Rouleau
(G)
Claire Slaney
(C)
Gustavo Turecki
(G)
L Trevor Young
(LT)
Carlos A López Jaramillo
(CAL)
Tomás Novák
(T)
Pavla Stopkova
(P)
Clara Brichant-Petitjean
(C)
Bruno Etain
(B)
Mazda Adli
(M)
Sébastien Gard
(S)
Stéphane Jamain
(S)
Jean-Pierre Kahn
(JP)
Marion Leboyer
(M)
Mazda Adli
(M)
Michael Bauer
(M)
Sven Cichon
(S)
Franziska Degenhardt
(F)
Peter Falkai
(P)
Oliver Gruber
(O)
Urs Heilbronner
(U)
Per Hoffmann
(P)
Sarah Kittel-Schneider
(S)
Markus Nöthen
(M)
Andrea Pfennig
(A)
Daniela Reich-Erkelenz
(D)
Andreas Reif
(A)
Marcella Rietschel
(M)
Thomas G Schulze
(TG)
Florian Seemüller
(F)
Thomas Stamm
(T)
Raffaella Ardau
(R)
Caterina Chillotti
(C)
Maria Del Zompo
(M)
Maria Del Zompo
(M)
Mario Maj
(M)
Mirko Manchia
(M)
Palmiero Monteleone
(P)
Giovanni Severino
(G)
Alessio Squassina
(A)
Alfonso Tortorella
(A)
Kazufumi Akiyama
(K)
Ryota Hashimoto
(R)
Ichiro Kusumi
(I)
Takuya Masui
(T)
Norio Ozaki
(N)
Piotr Czerski
(P)
Joanna Hauser
(J)
Sebastian Kliwicki
(S)
Janusz K Rybakowski
(JK)
Maria Grigoroiu-Serbanescu
(M)
Alexandru Obregia
(A)
Bárbara Arias
(B)
Antonio Benabarre
(A)
Francesc Colom
(F)
Esther Jiménez
(E)
Marina Mitjans
(M)
Eduard Vieta
(E)
Lena Backlund
(L)
Louise Frisén
(L)
Catharina Lavebratt
(C)
Lina Martinsson
(L)
Urban Ösby
(U)
Martin Schalling
(M)
Jean-Michel Aubry
(JM)
Sven Cichon
(S)
Alexandre Dayer
(A)
Per Hoffmann
(P)
Audrey Nallet
(A)
Hsi-Chung Chen
(HC)
David Cousins
(D)
Nirmala Akula
(N)
Joanna M Biernacka
(JM)
Elise T Bui
(ET)
J Ray DePaulo
(JR)
Sevilla D Detera-Wadleigh
(SD)
Mark A Frye
(MA)
Fernando S Goes
(FS)
Rebecca Hoban
(R)
Liping Hou
(L)
Layla Kassem
(L)
John R Kelsoe
(JR)
Gonzalo Laje
(G)
Susan G Leckband
(SG)
Michael J McCarthy
(MJ)
Francis J McMahon
(FJ)
Roy H Perlis
(RH)
James B Potash
(JB)
Thomas G Schulze
(TG)
Barbara Schweizer
(B)
Lisa R Seymour
(LR)
Jordan W Smoller
(JW)
Jo Steele
(J)
Sarah Tighe
(S)
Peter P Zandi
(PP)
Informations de copyright
© 2022. The Author(s).
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