Risk factors for tumors or leukemia development in the first two years of life.
early-aged period
epidemiology
neoplastic disease
risk factors
Journal
Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia
ISSN: 1804-7521
Titre abrégé: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub
Pays: Czech Republic
ID NLM: 101140142
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
received:
15
10
2021
accepted:
25
01
2022
medline:
3
11
2023
pubmed:
12
2
2022
entrez:
11
2
2022
Statut:
ppublish
Résumé
The objective of this study was to determine the incidence of neoplastic diseases and associated risk factors in the early stages of life. Data were retrospectively assessed in 730,000 live births between 2000 and 2019. The occurrence of tumors was monitored in the neonatal, infant (1-12 months), and toddler (13-24 months) periods. Risk factors were divided into demographic, internal, and environmental factors. The control group consisted of subjects in the same age category without oncological diseases. A total of 452 neoplastic diseases were diagnosed in the study sample. In total, 24% (110/452) manifested during the neonatal period, 45% (203/452) in infants, and 31% (139/452) at the age of 13-24 months. Any genetic disease (OR 26.68; 95% CI 7.64-93.12) and medications used by the mother (OR 3.07; 95% CI 1.32-7.15) were identified as risk factors. Without adjustment for all factors, asphyxia in the first minute, a younger age of the mother, lower pregnancy, and the presence of a congenital defect manifested themselves as risk factors. The highest risk factors for the development of early childhood tumors were identified as with medications used by the mother before or during pregnancy and genetic diseases.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
246-253Déclaration de conflit d'intérêts
The authors report no conflicts of interest in this work.
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