Regulation of organelle size and organization during development.

Animals Organelle Size Xenopus laevis Cell Size Organelles
Cell size Chromosomes Development Nucleus Organelle size Spindle Xenopus

Journal

Seminars in cell & developmental biology
ISSN: 1096-3634
Titre abrégé: Semin Cell Dev Biol
Pays: England
ID NLM: 9607332

Informations de publication

Date de publication:
15 01 2023
Historique:
received: 15 11 2021
revised: 20 01 2022
accepted: 01 02 2022
pmc-release: 15 01 2024
pubmed: 13 2 2022
medline: 23 11 2022
entrez: 12 2 2022
Statut: ppublish

Résumé

During early embryogenesis, as cells divide in the developing embryo, the size of intracellular organelles generally decreases to scale with the decrease in overall cell size. Organelle size scaling is thought to be important to establish and maintain proper cellular function, and defective scaling may lead to impaired development and disease. However, how the cell regulates organelle size and organization are largely unanswered questions. In this review, we summarize the process of size scaling at both the cell and organelle levels and discuss recently discovered mechanisms that regulate this process during early embryogenesis. In addition, we describe how some recently developed techniques and Xenopus as an animal model can be used to investigate the underlying mechanisms of size regulation and to uncover the significance of proper organelle size scaling and organization.

Identifiants

DOI: 10.1016/j.semcdb.2022.02.002 PMID: 35148938 PMC: PMC9357868
pubmed: 35148938
pii: S1084-9521(22)00030-1
doi: 10.1016/j.semcdb.2022.02.002
pmc: PMC9357868
mid: NIHMS1778875
pii:
doi:

Types de publication

Journal Article Review Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

53-64

Subventions

Organisme : NIGMS NIH HHS
ID : P20 GM103432
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM134885
Pays : United States

Informations de copyright

Copyright © 2022 Elsevier Ltd. All rights reserved.

Auteurs

Pan Chen (P)

Institute of Biochemistry and Molecular Biology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, China. Electronic address: chenpan@nbu.edu.cn.

Daniel L Levy (DL)

Department of Molecular Biology, University of Wyoming, Laramie, WY 82071, USA. Electronic address: dlevy1@uwyo.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Regulation of organelle size and organization...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Taille de l'organelle › Regulation of organelle size and organization...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Amphibiens › Anura › Pipidae › Xenopus › Xenopus laevis › Regulation of organelle size and organization...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Taille de la cellule › Regulation of organelle size and organization...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Regulation of organelle size and organization...