The interactions of flaviviruses with cellular receptors: Implications for virus entry.
Attachment
Cellular receptors
Flaviviruses
Internalization
Membrane fusion
Journal
Virology
ISSN: 1096-0341
Titre abrégé: Virology
Pays: United States
ID NLM: 0110674
Informations de publication
Date de publication:
03 2022
03 2022
Historique:
received:
21
10
2021
revised:
10
01
2022
accepted:
02
02
2022
pubmed:
13
2
2022
medline:
15
3
2022
entrez:
12
2
2022
Statut:
ppublish
Résumé
Flaviviruses are a group of enveloped viruses that enter the host cells through receptor-mediated endocytosis. The entry of flaviviruses into the cells is a multi-step process which involves several host factors that trigger the uptake of the virus. The initial step in the virus life cycle is the interactions between viral envelope proteins and the specific receptors on the surface of host cell. To date, several receptors have been identified such as glycosaminoglycans, tight junction proteins, laminin receptor and phosphatidylserine receptors. Moreover, the viruses may utilize integrins and C-type lectin receptors on the surface of host cells as the initial attachment factors. This mini-review will focus on recent progresses in the understanding of virus attachment, internalization, and membrane fusion with specific emphasis on the cellular receptors.
Identifiants
pubmed: 35149346
pii: S0042-6822(22)00023-X
doi: 10.1016/j.virol.2022.02.001
pii:
doi:
Substances chimiques
Receptors, Virus
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
77-85Informations de copyright
Copyright © 2022 Elsevier Inc. All rights reserved.