Urinary cortisol-creatinine ratio in dogs with hypoadrenocorticism.
Addison's disease
adrenal insufficiency
canine
cortisol
Journal
Journal of veterinary internal medicine
ISSN: 1939-1676
Titre abrégé: J Vet Intern Med
Pays: United States
ID NLM: 8708660
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
revised:
26
12
2021
received:
04
10
2021
accepted:
06
01
2022
pubmed:
13
2
2022
medline:
1
4
2022
entrez:
12
2
2022
Statut:
ppublish
Résumé
Basal serum cortisol (BSC) ≥2 μg/dL (>55 nmol/L) has high sensitivity but low specificity for hypoadrenocorticism (HA). To determine whether the urinary corticoid:creatinine ratio (UCCR) can be used to differentiate dogs with HA from healthy dogs and those with diseases mimicking HA (DMHA). Nineteen healthy dogs, 18 dogs with DMHA, and 10 dogs with HA. Retrospective study. The UCCR was determined on urine samples from healthy dogs, dogs with DMHA, and dogs with HA. The diagnostic performance of the UCCR was assessed based on receiver operating characteristics (ROC) curves, calculating the area under the ROC curve. The UCCR was significantly lower in dogs with HA (0.65 × 10 The UCCR seems to be a valuable and reliable screening test for HA in dogs. The greatest advantage of this test is the need for only a single urine sample.
Sections du résumé
BACKGROUND
BACKGROUND
Basal serum cortisol (BSC) ≥2 μg/dL (>55 nmol/L) has high sensitivity but low specificity for hypoadrenocorticism (HA).
OBJECTIVE
OBJECTIVE
To determine whether the urinary corticoid:creatinine ratio (UCCR) can be used to differentiate dogs with HA from healthy dogs and those with diseases mimicking HA (DMHA).
ANIMALS
METHODS
Nineteen healthy dogs, 18 dogs with DMHA, and 10 dogs with HA.
METHODS
METHODS
Retrospective study. The UCCR was determined on urine samples from healthy dogs, dogs with DMHA, and dogs with HA. The diagnostic performance of the UCCR was assessed based on receiver operating characteristics (ROC) curves, calculating the area under the ROC curve.
RESULTS
RESULTS
The UCCR was significantly lower in dogs with HA (0.65 × 10
CONCLUSIONS AND CLINICAL IMPORTANCE
CONCLUSIONS
The UCCR seems to be a valuable and reliable screening test for HA in dogs. The greatest advantage of this test is the need for only a single urine sample.
Identifiants
pubmed: 35150029
doi: 10.1111/jvim.16358
pmc: PMC8965274
doi:
Substances chimiques
Creatinine
AYI8EX34EU
Hydrocortisone
WI4X0X7BPJ
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
482-487Subventions
Organisme : Laboratorio di Analisi Veterinarie MYLAV
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2022 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine.
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