The impact of neurotoxicant exposures on posttraumatic stress disorder trajectories: The Ft. Devens Gulf War Veterans Cohort.
Journal
Journal of traumatic stress
ISSN: 1573-6598
Titre abrégé: J Trauma Stress
Pays: United States
ID NLM: 8809259
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
received:
12
04
2021
accepted:
08
12
2021
pubmed:
13
2
2022
medline:
18
6
2022
entrez:
12
2
2022
Statut:
ppublish
Résumé
Gulf War veterans (GWVs) were exposed to neurotoxicants, including sarin nerve gas, anti-nerve agent pills, pesticides, oil well fires, and fumes from unvented tent heaters, all of which have been associated with subsequent adverse health. Posttraumatic stress disorder (PTSD) symptoms have also been associated with GW deployment; however, associations between exposures and PTSD symptoms have not been investigated. We assessed PTSD symptom trajectories and associations with neurotoxicant exposures in Ft. Devens Cohort (FDC) veterans (N = 259) who endorsed trauma exposure during deployment and completed the PTSD Checklist at three follow-ups (1992-1993, 1997-1998, 2013-2017). Results indicate that among veterans with more severe initial PTSD symptoms, symptoms remained significantly higher across follow-ups, Bs = -1.489-1.028, whereas among those with low initial PTSD symptoms, symptom severity increased significantly over time, Bs = 1.043-10.304. Additionally, neurotoxicant exposure was associated with a significant increase in PTSD symptoms, Bs = -1.870-9.003. Significant interactions between time and exposures were observed for PTSD symptom clusters, suggesting that among participants with high initial PTSD symptom, unexposed veterans experienced symptom alleviation, whereas exposed veterans' PTSD symptoms remained high. In GWVs with low initial PTSD symptoms, both unexposed and exposed veterans experienced PTSD symptom exacerbations over time; however, this occurred at a faster rate among exposed veterans. These findings suggest that in the years following deployment, GWVs who were exposed to both traumatic events and neurotoxicants may experience more severe and chronic PTSD symptoms than those without neurotoxicant exposures.
Identifiants
pubmed: 35150175
doi: 10.1002/jts.22802
pmc: PMC9541763
doi:
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
955-966Informations de copyright
© 2022 The Authors. Journal of Traumatic Stress published by Wiley Periodicals LLC on behalf of International Society for Traumatic Stress Studies.
Références
Biometrics. 1986 Mar;42(1):121-30
pubmed: 3719049
Am J Ind Med. 1998 Feb;33(2):104-13
pubmed: 9438043
Behav Res Ther. 2000 Feb;38(2):203-14
pubmed: 10661004
Int J Environ Res Public Health. 2019 Mar 16;16(6):
pubmed: 30884809
J Trauma Stress. 2004 Jun;17(3):195-202
pubmed: 15253091
J Nerv Ment Dis. 2004 Feb;192(2):146-52
pubmed: 14770059
Am J Epidemiol. 2000 Nov 15;152(10):992-1002
pubmed: 11092441
Cogn Affect Behav Neurosci. 2020 Jun;20(3):455-480
pubmed: 32170605
Psychol Bull. 1992 Sep;112(2):218-38
pubmed: 1454893
J Clin Psychiatry. 2013 Dec;74(12):e1163-8
pubmed: 24434104
Neurotoxicology. 2016 Mar;53:246-256
pubmed: 26920621
BMC Res Notes. 2019 Dec 18;12(1):816
pubmed: 31852524
JAMA. 1991 Aug 7;266(5):693-5
pubmed: 2072481
Am J Psychiatry. 1995 Aug;152(8):1150-5
pubmed: 7625462
J Neurotrauma. 2018 Jan 15;35(2):210-225
pubmed: 29017388
J Trauma Stress. 2022 Jun;35(3):955-966
pubmed: 35150175
J Psychiatr Res. 2019 Dec;119:23-31
pubmed: 31546045
Psychiatry Clin Neurosci. 2004 Dec;58(6):624-9
pubmed: 15601387
Extrem Physiol Med. 2016 Jul 15;5:8
pubmed: 27429749
J Womens Health (Larchmt). 2015 Dec;24(12):1038-46
pubmed: 26204466
Curr Psychiatry Rep. 2019 Jun 6;21(7):58
pubmed: 31172321
JAMA Psychiatry. 2015 Sep;72(9):875-81
pubmed: 26201054
J Ment Health Clin Psychol. 2018 Oct 1;2(5):9-14
pubmed: 30957105
Brain Behav Immun. 2020 Jul;87:498-507
pubmed: 32027960
J Occup Environ Med. 2020 Sep;62(9):663-668
pubmed: 32890202
J Occup Environ Med. 2002 Mar;44(3):271-81
pubmed: 11911029
Cortex. 2016 Jan;74:449-75
pubmed: 26493934
Neuroimage. 2005 Mar;25(1):43-50
pubmed: 15734342
Brain Sci. 2018 Nov 13;8(11):
pubmed: 30428552
J Clin Psychiatry. 2016 Mar;77(3):348-54
pubmed: 27046308
Neurosci Res. 2005 Jun;52(2):129-31
pubmed: 15876465
J Abnorm Psychol. 2000 May;109(2):205-13
pubmed: 10895558
Am J Epidemiol. 2016 Dec 1;184(11):796-805
pubmed: 27852604
Neurotoxicology. 2006 Dec;27(6):931-9
pubmed: 16982099
Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4295-300
pubmed: 18332428
Int J Epidemiol. 1998 Dec;27(6):1000-10
pubmed: 10024195
Gerontologist. 2016 Feb;56(1):14-21
pubmed: 26553735
Am J Epidemiol. 2003 Jan 15;157(2):141-8
pubmed: 12522021