Bis-nor-diterpene from Cnidoscolus quercifolius (Euphorbiaceae) induces tubulin depolymerization-mediated apoptosis in BRAF-mutated melanoma cells.
Antineoplastic Agents, Phytogenic
/ chemistry
Apoptosis
/ drug effects
Binding Sites
Cell Cycle Checkpoints
/ drug effects
Cell Line, Tumor
Cell Movement
Colchicine
/ chemistry
Diterpenes
/ chemistry
Euphorbiaceae
/ chemistry
Humans
Melanoma
/ metabolism
Molecular Docking Simulation
Mutation
Plant Bark
/ chemistry
Plant Extracts
/ chemistry
Proto-Oncogene Proteins B-raf
/ genetics
Tubulin
/ chemistry
Apoptosis
Cancer
Cytoskeleton
Diterpene
Melanoma
Journal
Chemico-biological interactions
ISSN: 1872-7786
Titre abrégé: Chem Biol Interact
Pays: Ireland
ID NLM: 0227276
Informations de publication
Date de publication:
01 Mar 2022
01 Mar 2022
Historique:
received:
28
10
2021
revised:
27
01
2022
accepted:
07
02
2022
pubmed:
13
2
2022
medline:
8
3
2022
entrez:
12
2
2022
Statut:
ppublish
Résumé
A phytochemical investigation of cytotoxic extract and fractions of Cnidoscolus quercifolius Pohl led to isolation of five terpenoids, including three lupane-type triterpenes (1-3) and two bis-nor-diterpenes (4-5). Compounds 4 (phyllacanthone) and 5 (favelanone) are commonly found in this species and have unique chemical structure. Although their cytotoxic activity against cancer cells has been previously reported, the anticancer potential of these molecules remains poorly explored. In this paper, the antimelanoma potential of phyllacanthone (PHY) was described for the first time. Cell viability assay showed a promising cytotoxic activity (IC
Identifiants
pubmed: 35150652
pii: S0009-2797(22)00054-0
doi: 10.1016/j.cbi.2022.109849
pii:
doi:
Substances chimiques
Antineoplastic Agents, Phytogenic
0
Diterpenes
0
Plant Extracts
0
Tubulin
0
Proto-Oncogene Proteins B-raf
EC 2.7.11.1
Colchicine
SML2Y3J35T
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
109849Informations de copyright
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