Prefrontal cortical distribution of muscarinic M2 and cannabinoid-1 (CB1) receptors in adult male mice with or without chronic adolescent exposure to Δ9-tetrahydrocannabinol.
cannabinoid
cholinergic
marijuana
prelimbic
ultrastructure
Journal
Cerebral cortex (New York, N.Y. : 1991)
ISSN: 1460-2199
Titre abrégé: Cereb Cortex
Pays: United States
ID NLM: 9110718
Informations de publication
Date de publication:
21 11 2022
21 11 2022
Historique:
received:
05
08
2021
revised:
05
01
2022
accepted:
06
01
2022
pubmed:
13
2
2022
medline:
3
12
2022
entrez:
12
2
2022
Statut:
ppublish
Résumé
Chronic adolescent administration of marijuana's major psychoactive compound, ∆9-tetrahydrocannabinol (Δ9-THC), produces adaptive changes in adult social and cognitive functions sustained by prelimbic prefrontal cortex (PL-PFC). Memory and learning processes in PL-PFC neurons can be regulated through cholinergic muscarinic-2 receptors (M2R) and modulated by activation of cannabinoid-1 receptors (CB1Rs) targeted by Δ9-THC. Thus, chronic exposure to Δ9-THC during adolescence may alter the expression and/or distribution of M2Rs in PL-PFC neurons receiving CB1R terminals. We tested this hypothesis by using electron microscopic dual CB1R and M2R immunolabeling in adult C57BL/6 J male mice that had received vehicle or escalating dose of Δ9-THC through adolescence. In vehicle controls, CB1R immunolabeling was mainly localized to axonal profiles virtually devoid of M2R but often apposing M2R-immunoreactive dendrites and dendritic spines. The dendrites received inputs from CB1R-labeled or unlabeled terminals, whereas spines received asymmetric synapses exclusively from axon terminals lacking CB1Rs. Adolescent Δ9-THC significantly increased plasmalemmal M2R-immunogold density exclusively in large dendrites receiving input from CB1R-labeled terminals. In contrast, cytoplasmic M2R-immunogold density decreased in small spines of the Δ9-THC-treated adult mice. We conclude that Δ9-THC engagement of CB1Rs during adolescence increases M2R plasmalemmal accumulation in large proximal dendrites and decreases M2R cytoplasmic expression in small spines of PL-PFC.
Identifiants
pubmed: 35151230
pii: 6527551
doi: 10.1093/cercor/bhac024
pmc: PMC9712711
doi:
Substances chimiques
Dronabinol
7J8897W37S
Receptor, Cannabinoid, CB1
0
Receptor, Muscarinic M2
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
5420-5437Subventions
Organisme : NIDA NIH HHS
ID : R01 DA042943
Pays : United States
Organisme : NIDA NIH HHS
ID : DA043982
Pays : United States
Informations de copyright
© The Author(s) 2022. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Références
Neurosci Biobehav Rev. 2003 Oct;27(6):555-79
pubmed: 14599436
Science. 2007 May 25;316(5828):1212-6
pubmed: 17525344
J Neurosci. 2002 Mar 1;22(5):1709-17
pubmed: 11880500
Br J Pharmacol. 2010 Sep;161(1):103-12
pubmed: 20718743
J Neurophysiol. 1997 Jul;78(1):43-50
pubmed: 9242259
Neuron. 2012 Oct 4;76(1):70-81
pubmed: 23040807
Proc Natl Acad Sci U S A. 1999 May 11;96(10):5786-90
pubmed: 10318962
J Physiol. 2004 Apr 1;556(Pt 1):95-107
pubmed: 14742727
J Comp Neurol. 2000 Mar 27;419(1):32-48
pubmed: 10717638
Life Sci. 2002 Dec 20;72(4-5):397-407
pubmed: 12467880
Nat Rev Neurosci. 2021 Jul;22(7):423-438
pubmed: 34021274
Br J Pharmacol. 2014 Mar;171(6):1435-47
pubmed: 24236988
J Mol Neurosci. 2010 Jul;41(3):340-6
pubmed: 20446119
Naunyn Schmiedebergs Arch Pharmacol. 2001 Jan;363(1):50-6
pubmed: 11191836
Neurosci Biobehav Rev. 2000 Jun;24(4):417-63
pubmed: 10817843
J Comp Neurol. 1993 Jan 22;327(4):535-50
pubmed: 8440779
Eur J Pharmacol. 2001 May 11;419(2-3):155-61
pubmed: 11426837
Eur J Pharmacol. 1998 Aug 21;355(2-3):119-24
pubmed: 9760025
J Comp Neurol. 2008 Mar 10;507(2):1258-76
pubmed: 18181146
Neuroscience. 1998 Jan;82(2):355-76
pubmed: 9466448
Methods Enzymol. 2013;521:171-87
pubmed: 23351739
Science. 1987 May 1;236(4801):600-5
pubmed: 3107123
J Comp Neurol. 1998 Jan 5;390(1):112-32
pubmed: 9456180
J Neurosci. 1991 Oct;11(10):3218-26
pubmed: 1941081
J Neurophysiol. 2012 Sep;108(6):1656-68
pubmed: 22723675
J Alzheimers Dis. 2014;40(3):701-12
pubmed: 24496074
J Neurosci. 2006 Aug 23;26(34):8829-37
pubmed: 16928872
Psychopharmacology (Berl). 2011 Oct;217(4):485-94
pubmed: 21559804
Neurosci Biobehav Rev. 2006;30(5):680-95
pubmed: 16574226
J Neurosci. 1999 Jun 1;19(11):4544-58
pubmed: 10341254
Brain Res. 1991 May 3;547(2):267-74
pubmed: 1909204
Eur J Neurosci. 2008 Feb;27(3):654-70
pubmed: 18279318
J Comp Neurol. 1999 Jul 26;410(2):197-210
pubmed: 10414527
Biol Psychiatry. 2016 Apr 1;79(7):578-85
pubmed: 26344755
J Comp Neurol. 2000 Jun 26;422(2):159-71
pubmed: 10842224
Pediatr Clin North Am. 2002 Apr;49(2):389-413
pubmed: 11993290
Br J Pharmacol. 2000 Oct;131(3):645-50
pubmed: 11015319
Neurobiol Dis. 2015 Jan;73:60-9
pubmed: 25281318
IBRO Neurosci Rep. 2021 Oct 01;11:144-155
pubmed: 34667972
J Comp Neurol. 1985 Apr 1;234(1):17-34
pubmed: 3980786
Prog Brain Res. 2004;145:59-66
pubmed: 14650906
J Comp Neurol. 2012 Dec 1;520(17):4013-31
pubmed: 22592925
Chem Phys Lipids. 2002 Dec 31;121(1-2):83-9
pubmed: 12505693
Brain Res Mol Brain Res. 1994 Jan;21(1-2):30-46
pubmed: 8164520
Neuropsychopharmacology. 2020 Jan;45(2):374-383
pubmed: 31323660
Cereb Cortex. 2007 Jan;17(1):175-91
pubmed: 16467563
Trends Pharmacol Sci. 2001 Nov;22(11):565-72
pubmed: 11698100
BMC Neurosci. 2012 Apr 27;13:42
pubmed: 22540185
Proc Natl Acad Sci U S A. 1990 Sep;87(18):7050-4
pubmed: 2402490
Science. 1987 Jul 31;237(4814):527-32
pubmed: 3037705
Neuron. 1993 Oct;11(4):771-87
pubmed: 8104433
Neurosci Res. 2002 Apr;42(4):243-50
pubmed: 11985876
J Comp Neurol. 2003 Jun 9;462(3):302-14
pubmed: 12794734
Eur J Neurosci. 1996 Jul;8(7):1488-500
pubmed: 8758956
Neuropharmacology. 2001 Sep;41(3):392-9
pubmed: 11522331
J Comp Neurol. 1995 Jul 17;358(1):88-101
pubmed: 7560279
J Physiol. 2009 Nov 1;587(Pt 21):5139-47
pubmed: 19752120
Neurochem Res. 2015 Dec;40(12):2600-14
pubmed: 25894681
Neurosci Lett. 1995 Apr 28;190(1):53-6
pubmed: 7624055
J Neurocytol. 2002 Mar-Jun;31(3-5):299-316
pubmed: 12815249
J Neurosci Methods. 1990 Aug;33(2-3):113-27
pubmed: 1977960
J Neurosci. 1995 Apr;15(4):2948-60
pubmed: 7722639
J Histochem Cytochem. 1981 Apr;29(4):577-80
pubmed: 6166661
Synapse. 2018 Mar;72(3):
pubmed: 29178372
J Physiol. 2001 Sep 1;535(Pt 2):383-96
pubmed: 11533131
J Neurosci. 2005 Jul 20;25(29):6845-56
pubmed: 16033894
Front Cell Neurosci. 2018 Nov 30;12:450
pubmed: 30555302
Neurosci Lett. 2000 Apr 28;284(3):182-6
pubmed: 10773429
J Comp Neurol. 2006 Oct 20;498(6):821-39
pubmed: 16927256
Mol Cell Endocrinol. 2008 Apr 16;286(1-2 Suppl 1):S108-13
pubmed: 18358595
Neuroscience. 2013 Apr 3;235:40-50
pubmed: 23333674
Exp Neurol. 1997 Apr;144(2):361-8
pubmed: 9168836
Prog Brain Res. 2002;136:145-55
pubmed: 12143378
Naunyn Schmiedebergs Arch Pharmacol. 2012 Apr;385(4):385-96
pubmed: 22215206
Proc Natl Acad Sci U S A. 1993 Jun 1;90(11):5194-8
pubmed: 8389473
Prog Brain Res. 2004;145:45-58
pubmed: 14650905
J Neurosci. 1991 Feb;11(2):563-83
pubmed: 1992016
Biochem Pharmacol. 2018 Nov;157:210-216
pubmed: 30096288
J Anat. 1959 Oct;93:420-33
pubmed: 13829103
Brain Res Brain Res Rev. 1998 May;26(2-3):113-35
pubmed: 9651498
Neuroscience. 1999;92(4):1177-91
pubmed: 10426477
Handb Exp Pharmacol. 2005;(168):327-65
pubmed: 16596780
Neuropharmacology. 2018 Jun;135:22-33
pubmed: 29510186
Neuropharmacology. 2010 Jul-Aug;59(1-2):121-7
pubmed: 20417220
J Comp Neurol. 1995 Jul 10;357(4):603-17
pubmed: 7673486
J Comp Neurol. 2016 Oct 15;524(15):3084-103
pubmed: 27038330
Front Psychiatry. 2020 Nov 12;11:576214
pubmed: 33262712
Eur J Neurosci. 1999 Dec;11(12):4213-25
pubmed: 10594647
Neuroscience. 1992;47(2):367-93
pubmed: 1641129
Mol Cell Neurosci. 2003 May;23(1):121-33
pubmed: 12799142
J Neurosci. 2006 May 24;26(21):5628-37
pubmed: 16723519
Anat Embryol (Berl). 1994 Oct;190(4):307-37
pubmed: 7840420
J Cell Biol. 1963 Apr;17:208-12
pubmed: 13986422
Chem Phys Lipids. 2002 Dec 31;121(1-2):73-82
pubmed: 12505692
J Neurosci. 2001 Dec 1;21(23):9506-18
pubmed: 11717385
Methods Mol Biol. 2011;793:23-59
pubmed: 21913092
Nat Rev Neurosci. 2009 May;10(5):383-90
pubmed: 19377503
Neuroscience. 2012 Mar 1;204:145-58
pubmed: 22233782
J Neurochem. 2007 Aug;102(4):1105-14
pubmed: 17484726