Immuno-proteomic profiling reveals aberrant immune cell regulation in the airways of individuals with ongoing post-COVID-19 respiratory disease.
Adult
Aged
B-Lymphocytes
/ immunology
COVID-19
/ complications
Female
Follow-Up Studies
Humans
Immunity, Cellular
Immunoproteins
Male
Middle Aged
Monocytes
/ immunology
Proteome
Respiration Disorders
/ etiology
Respiratory System
/ immunology
SARS-CoV-2
/ physiology
T-Lymphocytes, Cytotoxic
/ immunology
COVID-19
SARS-CoV-2
T cells
airways
long COVID
proteomics
respiratory tract
respiratory viral infection
tissue-resident memory
Journal
Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918
Informations de publication
Date de publication:
08 03 2022
08 03 2022
Historique:
received:
10
08
2021
revised:
17
11
2021
accepted:
21
01
2022
pubmed:
14
2
2022
medline:
15
3
2022
entrez:
13
2
2022
Statut:
ppublish
Résumé
Some patients hospitalized with acute COVID-19 suffer respiratory symptoms that persist for many months. We delineated the immune-proteomic landscape in the airways and peripheral blood of healthy controls and post-COVID-19 patients 3 to 6 months after hospital discharge. Post-COVID-19 patients showed abnormal airway (but not plasma) proteomes, with an elevated concentration of proteins associated with apoptosis, tissue repair, and epithelial injury versus healthy individuals. Increased numbers of cytotoxic lymphocytes were observed in individuals with greater airway dysfunction, while increased B cell numbers and altered monocyte subsets were associated with more widespread lung abnormalities. A one-year follow-up of some post-COVID-19 patients indicated that these abnormalities resolved over time. In summary, COVID-19 causes a prolonged change to the airway immune landscape in those with persistent lung disease, with evidence of cell death and tissue repair linked to the ongoing activation of cytotoxic T cells.
Identifiants
pubmed: 35151371
pii: S1074-7613(22)00046-2
doi: 10.1016/j.immuni.2022.01.017
pmc: PMC8789571
pii:
doi:
Substances chimiques
Immunoproteins
0
Proteome
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
542-556.e5Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S004068/2
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/V027638/1
Pays : United Kingdom
Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.
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