Retinoic acid receptor beta protects striatopallidal medium spiny neurons from mitochondrial dysfunction and neurodegeneration.

Animals Glutamic Acid / metabolism Huntington Disease Mice Mitochondria / metabolism Neurons / metabolism Receptors, Retinoic Acid
Huntington’s disease Medium spiny neurons Mice models of movement disorders Mitochondria Motor behavior Nuclear hormone receptors Retinoic acid receptors Striatum

Journal

Progress in neurobiology
ISSN: 1873-5118
Titre abrégé: Prog Neurobiol
Pays: England
ID NLM: 0370121

Informations de publication

Date de publication:
05 2022
Historique:
received: 05 07 2021
revised: 07 12 2021
accepted: 04 02 2022
pubmed: 14 2 2022
medline: 6 5 2022
entrez: 13 2 2022
Statut: ppublish

Résumé

Retinoic acid is a powerful regulator of brain development, however its postnatal functions only start to be elucidated. We show that retinoic acid receptor beta (RARβ), is involved in neuroprotection of striatopallidal medium spiny neurons (spMSNs), the cell type affected in different neuropsychiatric disorders and particularly prone to degenerate in Huntington disease (HD). Accordingly, the number of spMSNs was reduced in the striatum of adult Rarβ

Identifiants

DOI: 10.1016/j.pneurobio.2022.102246 PMID: 35151792
pubmed: 35151792
pii: S0301-0082(22)00032-6
doi: 10.1016/j.pneurobio.2022.102246
pii:
doi:

Substances chimiques

Receptors, Retinoic Acid 0
retinoic acid receptor beta 0
Glutamic Acid 3KX376GY7L

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

102246

Informations de copyright

Copyright © 2022. Published by Elsevier Ltd.

Auteurs

Marion Ciancia (M)

Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), 67404 Illkirch, France; Inserm, U 1258, 67404 Illkirch, France; CNRS UMR 7104, 67404 Illkirch, France; Université de Strasbourg, 67404 Illkirch, France.

Monika Rataj-Baniowska (M)

Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), 67404 Illkirch, France; Inserm, U 1258, 67404 Illkirch, France; CNRS UMR 7104, 67404 Illkirch, France; Université de Strasbourg, 67404 Illkirch, France.

Nicolas Zinter (N)

Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), 67404 Illkirch, France; Inserm, U 1258, 67404 Illkirch, France; CNRS UMR 7104, 67404 Illkirch, France; Université de Strasbourg, 67404 Illkirch, France.

Vito Antonio Baldassarro (VA)

Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), 67404 Illkirch, France; Inserm, U 1258, 67404 Illkirch, France; CNRS UMR 7104, 67404 Illkirch, France; Université de Strasbourg, 67404 Illkirch, France; Department of Veterinary Medical Science (DIMEVET), University of Bologna, Ozzano Emilia (Bologna), Italy.

Valérie Fraulob (V)

Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), 67404 Illkirch, France; Inserm, U 1258, 67404 Illkirch, France; CNRS UMR 7104, 67404 Illkirch, France; Université de Strasbourg, 67404 Illkirch, France.

Anne-Laure Charles (AL)

Institut de Physiologie, Faculté de Médecine, "Mitochondrie, Stress Oxydant et Protection Musculaire", 4 Rue Kirschleger, 67085 Strasbourg, France.

Rosana Alvarez (R)

Departamento de Química Orgánica, Facultade de Química, CINBIO and IBIV, Universidade de Vigo, Campus As Lagoas-Marcosende, 36310 Vigo, Spain.

Shin-Ichi Muramatsu (SI)

Division of Neurological Gene Therapy, Center for Open Innovation, Jichi Medical University, Tochigi 3290498, Japan; Center for Gene and Cell Therapy, The Institute of Medical Science, The University of Tokyo, Tokyo 1088639, Japan.

Angel R de Lera (AR)

Departamento de Química Orgánica, Facultade de Química, CINBIO and IBIV, Universidade de Vigo, Campus As Lagoas-Marcosende, 36310 Vigo, Spain.

Bernard Geny (B)

Institut de Physiologie, Faculté de Médecine, "Mitochondrie, Stress Oxydant et Protection Musculaire", 4 Rue Kirschleger, 67085 Strasbourg, France.

Pascal Dollé (P)

Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), 67404 Illkirch, France; Inserm, U 1258, 67404 Illkirch, France; CNRS UMR 7104, 67404 Illkirch, France; Université de Strasbourg, 67404 Illkirch, France.

Anna Niewiadomska-Cimicka (A)

Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), 67404 Illkirch, France; Inserm, U 1258, 67404 Illkirch, France; CNRS UMR 7104, 67404 Illkirch, France; Université de Strasbourg, 67404 Illkirch, France.

Wojciech Krężel (W)

Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), 67404 Illkirch, France; Inserm, U 1258, 67404 Illkirch, France; CNRS UMR 7104, 67404 Illkirch, France; Université de Strasbourg, 67404 Illkirch, France. Electronic address: krezel@igbmc.fr.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Retinoic acid receptor beta protects...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés excitateurs › Acide glutamique › Retinoic acid receptor beta protects...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie de Huntington › Retinoic acid receptor beta protects...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Retinoic acid receptor beta protects...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › Retinoic acid receptor beta protects...
questionsmedicales.fr › Cellules › Neurones › Retinoic acid receptor beta protects...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Récepteurs à l'acide rétinoïque › Retinoic acid receptor beta protects...