Bone tissue engineering: Anionic polysaccharides as promising scaffolds.
Animals
Anions
/ chemistry
Biocompatible Materials
/ chemistry
Biomimetic Materials
/ pharmacology
Bone Regeneration
/ drug effects
Bone and Bones
/ metabolism
Cell Adhesion
/ drug effects
Glycosaminoglycans
/ chemistry
Humans
Male
Osteogenesis
/ drug effects
Polymers
/ chemistry
Polysaccharides
/ chemistry
Porosity
Rats
Tissue Engineering
/ methods
Tissue Scaffolds
/ chemistry
Bone regeneration
Glycosaminoglycans
Osteogenesis
Journal
Carbohydrate polymers
ISSN: 1879-1344
Titre abrégé: Carbohydr Polym
Pays: England
ID NLM: 8307156
Informations de publication
Date de publication:
01 May 2022
01 May 2022
Historique:
received:
27
10
2021
revised:
22
12
2021
accepted:
10
01
2022
entrez:
14
2
2022
pubmed:
15
2
2022
medline:
23
2
2022
Statut:
ppublish
Résumé
Bone repair is a self-healing process. However, critical-sized bone defects need bone augmentation where bone tissue engineering plays vital role. Bone tissue Engineering (BTE) requires unique combinations of scaffolds, cells, and bio-signal molecules. Bone scaffold materials should be biocompatible, bioresorbable and exhibit biomimetic properties. Natural polymers, acquiring cell binding motives, producing nontoxic degradation products and tunable properties are ideal materials. Anionic polysaccharides of natural origin mimic mammalian ECM components and even the group called GAGs (Glycosaminoglycan) are actual components of ECM possessing various functions including cell adhesion, cell signaling, maintenance of homeostasis and inflammation control. Among them, anionic polysaccharides provide stabilization and sustained release of growth factors (GFs), porosity, calcium phosphate nucleation site, viscoelasticity, and water retention. Therefore, anionic polysaccharides are unique biomaterials for BTE. In this review, we have summarized the highlights of bone tissue engineering and recent applications of anionic polysaccharides in BTE.
Identifiants
pubmed: 35153015
pii: S0144-8617(22)00046-7
doi: 10.1016/j.carbpol.2022.119142
pii:
doi:
Substances chimiques
Anions
0
Biocompatible Materials
0
Glycosaminoglycans
0
Polymers
0
Polysaccharides
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
119142Informations de copyright
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