Absorption, Distribution, Metabolism, and Excretion of [

Animals Carcinoma, Non-Small-Cell Lung Dogs Feces Glutathione Humans Lung Neoplasms Piperazines Proto-Oncogene Proteins p21(ras) Pyridines Pyrimidines Serum Albumin

Journal

Drug metabolism and disposition: the biological fate of chemicals
ISSN: 1521-009X
Titre abrégé: Drug Metab Dispos
Pays: United States
ID NLM: 9421550

Informations de publication

Date de publication:
05 2022
Historique:
received: 30 11 2021
accepted: 02 02 2022
pubmed: 15 2 2022
medline: 4 5 2022
entrez: 14 2 2022
Statut: ppublish

Résumé

Sotorasib is a first-in-class, targeted covalent inhibitor of Kirsten rat sarcoma viral oncogene homolog (KRAS)

Identifiants

DOI: 10.1124/dmd.121.000798 PMID: 35153196
pubmed: 35153196
pii: dmd.121.000798
doi: 10.1124/dmd.121.000798
doi:

Substances chimiques

Piperazines 0
Pyridines 0
Pyrimidines 0
Serum Albumin 0
sotorasib 2B2VM6UC8G
Proto-Oncogene Proteins p21(ras) EC 3.6.5.2
Glutathione GAN16C9B8O

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

600-612

Informations de copyright

Copyright © 2022 by The American Society for Pharmacology and Experimental Therapeutics.

Auteurs

Upendra P Dahal (UP)

Pharmacokinetics and Drug Metabolism, Amgen, Inc., South San Francisco, California.

Brooke M Rock (BM)

Pharmacokinetics and Drug Metabolism, Amgen, Inc., South San Francisco, California.

John Rodgers (J)

Pharmacokinetics and Drug Metabolism, Amgen, Inc., South San Francisco, California.

Xiaomeng Shen (X)

Pharmacokinetics and Drug Metabolism, Amgen, Inc., South San Francisco, California.

Zhe Wang (Z)

Pharmacokinetics and Drug Metabolism, Amgen, Inc., South San Francisco, California.

Jan L Wahlstrom (JL)

Pharmacokinetics and Drug Metabolism, Amgen, Inc., South San Francisco, California janw@amgen.com.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Absorption, Distribution, Metabolism, and...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Tumeurs des bronches › Carcinome bronchogénique › Carcinome pulmonaire non à petites cellules › Absorption, Distribution, Metabolism, and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Carnivora › Pinnipedia › Canidae › Chiens › Absorption, Distribution, Metabolism, and...
questionsmedicales.fr › Liquides et sécrétions biologiques › Fèces › Absorption, Distribution, Metabolism, and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Oligopeptides › Glutathion › Absorption, Distribution, Metabolism, and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Absorption, Distribution, Metabolism, and...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Absorption, Distribution, Metabolism, and...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pipérazines › Absorption, Distribution, Metabolism, and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Protéines proto-oncogènes p21(ras) › Absorption, Distribution, Metabolism, and...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyridines › Absorption, Distribution, Metabolism, and...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrimidines › Absorption, Distribution, Metabolism, and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du sang › Sérumalbumine › Absorption, Distribution, Metabolism, and...