Modeling Large Vessel Occlusion Stroke for the Evaluation of Endovascular Therapy According to Thrombus Composition.
endovascular therapy (EVT)
ischemic stroke
large vessel occlusion (LVO)
pathophysiology
thrombectomy simulation
thrombus
Journal
Frontiers in neurology
ISSN: 1664-2295
Titre abrégé: Front Neurol
Pays: Switzerland
ID NLM: 101546899
Informations de publication
Date de publication:
2021
2021
Historique:
received:
15
11
2021
accepted:
22
12
2021
entrez:
14
2
2022
pubmed:
15
2
2022
medline:
15
2
2022
Statut:
epublish
Résumé
More than 40% of endovascular therapy (EVT) fail to achieve complete reperfusion of the territory of the occluded artery in patients with acute ischemic stroke (AIS). Understanding factors influencing EVT could help overcome its limitations. Our objective was to study the impact of thrombus cell composition on EVT procedures, using a simulation system for modeling thrombus-induced large vessel occlusion (LVO) in flow conditions. In an open comparative trial, we analyzed the behavior of size-standardized platelet-rich and red blood cells (RBC)-rich thrombi during simulated stent retriever-mediated EVT procedures. Sixteen simulated EVT procedures were performed (8 RBC- vs. 8 platelet-rich thrombi). Platelet-rich thrombi were associated with a higher number of stent retriever passes (
Identifiants
pubmed: 35153990
doi: 10.3389/fneur.2021.815814
pmc: PMC8829452
doi:
Types de publication
Journal Article
Langues
eng
Pagination
815814Informations de copyright
Copyright © 2022 Freiherr von Seckendorff, Delvoye, Levant, Solo Nomenjanahary, Ollivier, Bourrienne, Di Meglio, Piotin, Escalard, Maier, Hebert, Smajda, Redjem, Mazighi, Blanc, Ho-Tin-Noé and Désilles.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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