Activated molecular probes for enzyme recognition and detection.
biosensor
enzyme
fluorescence imaging (FLI)
molecular probe
photoacoustic imaging
Journal
Theranostics
ISSN: 1838-7640
Titre abrégé: Theranostics
Pays: Australia
ID NLM: 101552395
Informations de publication
Date de publication:
2022
2022
Historique:
received:
31
08
2021
accepted:
09
12
2021
entrez:
14
2
2022
pubmed:
15
2
2022
medline:
22
4
2022
Statut:
epublish
Résumé
Exploring and understanding the interaction of changes in the activities of various enzymes, such as proteases, phosphatases, and oxidoreductases with tumor invasion, proliferation, and metastasis is of great significance for early cancer diagnosis. To detect the activity of tumor-related enzymes, various molecular probes have been developed with different imaging methods, including optical imaging, photoacoustic imaging (PAI), magnetic resonance imaging, positron emission tomography, and so on. In this review, we first describe the biological functions of various enzymes and the selectively recognized chemical linkers or groups. Subsequently, we systematically summarize the design mechanism of imaging probes and different imaging methods. Finally, we explore the challenges and development prospects in the field of enzyme activity detection. This comprehensive review will provide more insight into the design and development of enzyme activated molecular probes.
Identifiants
pubmed: 35154500
doi: 10.7150/thno.66676
pii: thnov12p1459
pmc: PMC8771559
doi:
Substances chimiques
Molecular Probes
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1459-1485Informations de copyright
© The author(s).
Déclaration de conflit d'intérêts
Competing Interests: The authors have declared that no competing interest exists.
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