Serum lactate dehydrogenase levels predict the prognosis of patients with soft tissue sarcoma.
LDH
Warburg effect
metastasis
prognosis
soft tissue sarcoma
Journal
Molecular and clinical oncology
ISSN: 2049-9469
Titre abrégé: Mol Clin Oncol
Pays: England
ID NLM: 101613422
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
received:
17
10
2021
accepted:
12
01
2022
entrez:
14
2
2022
pubmed:
15
2
2022
medline:
15
2
2022
Statut:
ppublish
Résumé
Several studies have reported the prognostic factors for soft tissue sarcoma. Although serum lactate dehydrogenase (LDH) levels are associated with poor prognosis in several types of cancer, their role in soft tissue sarcomas remains unclear. Therefore, the present study evaluated the association between serum LDH levels and the clinical characteristics and prognosis of soft tissue sarcoma. A total of 103 patients diagnosed with primary soft tissue sarcoma between 2003 and 2019 were retrospectively examined, and the association between serum LDH levels at the first visit and clinical characteristics were analysed. In high-grade soft tissue sarcoma, the association between survival and clinical characteristics, including stratified LDH levels, was also analysed. Serum LDH levels were stratified (>253 and ≤253 IU/l) according to the standard values used at our institution. High serum LDH levels were significantly associated with the presence of metastasis and histological grade (P<0.001 and 0.040, respectively). In both the univariate and multivariate analyses, disease-specific survival (DSS) was significantly worse in patients with high-grade soft tissue sarcoma and high serum LDH levels than in patients with normal serum LDH levels (univariate analysis: P=0.025; multivariate analysis: Hazard ratio, 4.60; 95% confidence interval, 1.16-18.2; P=0.030). In conclusion, high serum LDH levels at the first visit predicted the presence of distant metastasis, high histological grade and worse DSS in patients with high-grade soft tissue sarcoma. Therefore, in patients with high serum LDH levels at the first visit, these risks should be considered during pretreatment examinations and post-treatment follow-up.
Identifiants
pubmed: 35154705
doi: 10.3892/mco.2022.2498
pii: MCO-16-3-02498
pmc: PMC8822601
doi:
Types de publication
Journal Article
Langues
eng
Pagination
65Informations de copyright
Copyright: © Fujibuchi et al.
Déclaration de conflit d'intérêts
The authors declare that they have no competing interests.
Références
Front Biosci (Landmark Ed). 2015 Jun 01;20:1234-49
pubmed: 25961554
Eur J Clin Chem Clin Biochem. 1997 Aug;35(8):569-79
pubmed: 9298346
J Clin Oncol. 2014 Mar 1;32(7):671-7
pubmed: 24449231
Medicine (Baltimore). 2018 Sep;97(36):e12176
pubmed: 30200120
Ann Oncol. 1997 Aug;8(8):765-71
pubmed: 9332684
Med Oncol. 2013;30(3):624
pubmed: 23749307
Ann Surg Oncol. 2014 Mar;21(3):778-85
pubmed: 24306668
PLoS One. 2014 Sep 10;9(9):e107297
pubmed: 25207808
Eur J Cancer. 2012 Mar;48(4):501-9
pubmed: 22226571
Cancer. 2012 Feb 15;118(4):1055-61
pubmed: 21761398
BMC Cancer. 2018 Oct 3;18(1):942
pubmed: 30285656
Sci Rep. 2015 Apr 22;5:9800
pubmed: 25902419
Cancer. 2003 May 15;97(10):2530-43
pubmed: 12733153
PLoS One. 2019 Jul 1;14(7):e0219215
pubmed: 31260491
Mol Clin Oncol. 2016 Dec;5(6):832-838
pubmed: 28105365
Science. 1956 Feb 24;123(3191):309-14
pubmed: 13298683
Cancers (Basel). 2020 Mar 13;12(3):
pubmed: 32183216
Cell Biochem Biophys. 2014 Jul;69(3):633-40
pubmed: 24554485
Cell Biochem Funct. 1984 Jul;2(3):131-4
pubmed: 6383647
IUBMB Life. 2013 Nov;65(11):904-10
pubmed: 24265197
Science. 2009 May 22;324(5930):1029-33
pubmed: 19460998
J Surg Oncol. 2013 Dec;108(7):481-5
pubmed: 24018883
J Neurooncol. 2017 Jan;131(2):313-320
pubmed: 27752884
J Clin Oncol. 2011 Oct 20;29(30):4029-35
pubmed: 21931025
Dan Med J. 2014 Nov;61(11):B4957
pubmed: 25370967
Biomarkers. 2012 Sep;17(6):539-44
pubmed: 22793493
Anticancer Res. 2019 Dec;39(12):6871-6875
pubmed: 31810955
Eur J Cancer. 2003 Jan;39(1):19-30
pubmed: 12504654
Cancer Biomark. 2016;16(3):333-42
pubmed: 26835589
Eur J Cancer. 2004 Jan;40(1):73-83
pubmed: 14687792
PLoS One. 2013 Nov 28;8(11):e81624
pubmed: 24312329
Acta Orthop. 2014 Jun;85(3):323-32
pubmed: 24694277
Cancer Sci. 2012 Sep;103(9):1695-700
pubmed: 22642767
Cancer. 2019 Oct 15;125(20):3595-3602
pubmed: 31287163
Eur J Cancer. 2013 Jul;49(10):2356-64
pubmed: 23541571
J Cancer Res Clin Oncol. 2014 Jul;140(7):1205-10
pubmed: 24682390