Sakuranetin exerts anticonvulsant effect in bicuculline-induced seizures.
epilepsy
flavonoids
hippocampus
neuroprotection
seizures
Journal
Fundamental & clinical pharmacology
ISSN: 1472-8206
Titre abrégé: Fundam Clin Pharmacol
Pays: England
ID NLM: 8710411
Informations de publication
Date de publication:
Aug 2022
Aug 2022
Historique:
revised:
10
02
2022
received:
15
06
2021
accepted:
11
02
2022
pubmed:
15
2
2022
medline:
15
7
2022
entrez:
14
2
2022
Statut:
ppublish
Résumé
Epilepsy is a chronic neurological disorder characterized by an abnormal, spontaneous, and synchronized neuronal hyperactivity. Therapeutic approaches for controlling epileptic seizures are associated with pharmacoresistance and side effects burden. Previous studies reported that different natural products may have neuroprotector effects. Sakuranetin (SAK) is a flavanone with antiparasitic, anti-inflammatory, antimutagenic, antiallergic, and antioxidant activity. In the present work, the effect of SAK on seizures in a model of status epilepticus induced by bicuculline (BIC) in mice was evaluated. Male Swiss mice received an intracerebroventricular injection (i.c.v.) of SAK (1, 10, or 20 mg/kg-SAK1, SAK10, or SAK20). Firstly, animals were evaluated in the open field (OF; 20 min), afterwards in the elevated plus maze (EPM) test (5 min). Next, 30 min prior the administration of BIC (1 mg/kg), mice received an injection of SAK (1 or 10 mg/kg, i.c.v.) and were observed in the OF (20 min) for seizures assessment. After behavioral procedures, immunohistochemical analysis of c-Fos was performed. Our main results showed that the lowest doses of SAK (1 and 10 mg/kg) increased the total distance traveled in the OF, moreover protected against seizures and death on the BIC-induced seizures model. Furthermore, SAK treatment reduced neuronal activity on the dentate gyrus of the BIC-treated animals. Taken together, our results suggest an anticonvulsant effect of SAK, which could be used for the development of anticonvulsants based on natural products from herbal source.
Substances chimiques
Anticonvulsants
0
Biological Products
0
Flavonoids
0
sakuranetin
3O38P61299
Bicuculline
Y37615DVKC
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
663-673Subventions
Organisme : Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
ID : 001
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico
ID : 425694/2016-0
Organisme : Fundação de Amparo à Pesquisa no Estado de São Paulo
ID : 2018/26609-5
Informations de copyright
© 2022 Société Française de Pharmacologie et de Thérapeutique.
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