Sexual dimorphism: increased sterol excretion leads to hypocholesterolaemia in female hyperbilirubinaemic Gunn rats.
Gilbert's syndrome
LDL receptor
SREBP
UGT1A1
bile acid metabolism
cholesterol metabolism
lipid
unconjugated bilirubin
Journal
The Journal of physiology
ISSN: 1469-7793
Titre abrégé: J Physiol
Pays: England
ID NLM: 0266262
Informations de publication
Date de publication:
04 2022
04 2022
Historique:
received:
20
09
2021
accepted:
02
02
2022
pubmed:
15
2
2022
medline:
16
4
2022
entrez:
14
2
2022
Statut:
ppublish
Résumé
Circulating bilirubin is associated with reduced serum cholesterol concentrations in humans and in hyperbilirubinaemic Gunn rats. However, mechanisms contributing to hypocholesterolaemia remain unknown. Therefore, this study aimed to investigate cholesterol synthesis, transport and excretion in mutant Gunn rats. Adult Gunn and control rats were assessed for daily faecal sterol excretion using metabolic cages, and water was supplemented with [1-
Identifiants
pubmed: 35156712
doi: 10.1113/JP282395
pmc: PMC9310728
doi:
Substances chimiques
Lipoproteins, LDL
0
Receptors, LDL
0
Sterols
0
Cholesterol
97C5T2UQ7J
Bilirubin
RFM9X3LJ49
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1889-1911Informations de copyright
© 2022 The Authors. The Journal of Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society.
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