Oncolytic virus treatment differentially affects the CD56

NK cells cell cycle immunotherapy lymphocyte trafficking natural killer cells oncolytic virus proliferation reovirus

Journal

Immunology
ISSN: 1365-2567
Titre abrégé: Immunology
Pays: England
ID NLM: 0374672

Informations de publication

Date de publication:
05 2022
Historique:
received: 02 07 2021
accepted: 10 01 2022
pubmed: 15 2 2022
medline: 20 4 2022
entrez: 14 2 2022
Statut: ppublish

Résumé

Natural killer (NK) cells protect against intracellular infection and cancer. These properties are exploited in oncolytic virus (OV) therapy, where antiviral responses enhance anti-tumour immunity. We have analysed the mechanism by which reovirus, an oncolytic dsRNA virus, modulates human NK cell activity. Reovirus activates NK cells in a type I interferon (IFN-I) dependent manner, inducing STAT1 and STAT4 signalling in both CD56

Identifiants

pubmed: 35156714
doi: 10.1111/imm.13453
pmc: PMC10357483
doi:

Substances chimiques

Antiviral Agents 0
CD56 Antigen 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

104-120

Informations de copyright

© 2022 The Authors. Immunology published by John Wiley & Sons Ltd.

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Auteurs

Michelle Wantoch (M)

Leeds Institute of Medical Research, School of Medicine, University of Leeds, Leeds, UK.

Erica B Wilson (EB)

Leeds Institute of Medical Research, School of Medicine, University of Leeds, Leeds, UK.

Alastair P Droop (AP)

Leeds Institute of Medical Research, School of Medicine, University of Leeds, Leeds, UK.

Sarah L Phillips (SL)

Leeds Institute of Medical Research, School of Medicine, University of Leeds, Leeds, UK.

Matt Coffey (M)

Oncolytics Biotech Inc, Calgary, Alberta, Canada.

Yasser M El-Sherbiny (YM)

Leeds Institute of Medical Research, School of Medicine, University of Leeds, Leeds, UK.

Tim D Holmes (TD)

Leeds Institute of Medical Research, School of Medicine, University of Leeds, Leeds, UK.

Alan A Melcher (AA)

Leeds Institute of Medical Research, School of Medicine, University of Leeds, Leeds, UK.

Laura F Wetherill (LF)

Leeds Institute of Medical Research, School of Medicine, University of Leeds, Leeds, UK.

Graham P Cook (GP)

Leeds Institute of Medical Research, School of Medicine, University of Leeds, Leeds, UK.

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Classifications MeSH