High Metabolic Dependence on Oxidative Phosphorylation Drives Sensitivity to Metformin Treatment in
MLL/AF9
OXPHOS
heterogeneity
metformin
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
19 Jan 2022
19 Jan 2022
Historique:
received:
11
11
2021
revised:
10
01
2022
accepted:
15
01
2022
entrez:
15
2
2022
pubmed:
16
2
2022
medline:
16
2
2022
Statut:
epublish
Résumé
Acute myeloid leukemia (AML) is a group of hematological cancers with metabolic heterogeneity. Oxidative phosphorylation (OXPHOS) has been reported to play an important role in the function of leukemic stem cells and chemotherapy-resistant cells and are associated with inferior prognosis in AML patients. However, the relationship between metabolic phenotype and genetic mutations are yet to be explored. In the present study, we demonstrate that AML cell lines have high metabolic heterogeneity, and AML cells with
Identifiants
pubmed: 35158754
pii: cancers14030486
doi: 10.3390/cancers14030486
pmc: PMC8833593
pii:
doi:
Types de publication
Journal Article
Langues
eng
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