Expression of 3-Methylcrotonyl-CoA Carboxylase in Brain Tumors and Capability to Catabolize Leucine by Human Neural Cancer Cells.
3-methylcrotonyl-CoA carboxylase
acetyl-CoA
branched-chain amino acid
cancer cells
citrate
ketone bodies
leucine
metabolism
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
24 Jan 2022
24 Jan 2022
Historique:
received:
24
11
2021
revised:
20
01
2022
accepted:
21
01
2022
entrez:
15
2
2022
pubmed:
16
2
2022
medline:
16
2
2022
Statut:
epublish
Résumé
Leucine is an essential, ketogenic amino acid with proteinogenic, metabolic, and signaling roles. It is readily imported from the bloodstream into the brain parenchyma. Therefore, it could serve as a putative substrate that is complementing glucose for sustaining the metabolic needs of brain tumor cells. Here, we investigated the ability of cultured human cancer cells to metabolize leucine. Indeed, cancer cells dispose of leucine from their environment and enrich their media with the metabolite 2-oxoisocaproate. The enrichment of the culture media with a high level of leucine stimulated the production of 3-hydroxybutyrate. When
Identifiants
pubmed: 35158853
pii: cancers14030585
doi: 10.3390/cancers14030585
pmc: PMC8833481
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Slovak Research and Development Agency
ID : APVV-18-0088
Organisme : Qatar National Research Fund
ID : NPRP 11S-1214-170101
Organisme : Vedecká grantová agentúra MŠVVaŠ SR a SAV (VEGA)
ID : VEGA 1/0255/20
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