The Genomics of Hairy Cell Leukaemia and Splenic Diffuse Red Pulp Lymphoma.

BRAFV600E HCLc HCLv SDRPL Tbet hairy cell leukaemia

Journal

Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829

Informations de publication

Date de publication:
29 Jan 2022
Historique:
received: 29 12 2021
revised: 24 01 2022
accepted: 25 01 2022
entrez: 15 2 2022
pubmed: 16 2 2022
medline: 16 2 2022
Statut: epublish

Résumé

Classical hairy cell leukaemia (HCLc), its variant form (HCLv), and splenic diffuse red pulp lymphoma (SDRPL) constitute a subset of relatively indolent B cell tumours, with low incidence rates of high-grade transformations, which primarily involve the spleen and bone marrow and are usually associated with circulating tumour cells characterised by villous or irregular cytoplasmic borders. The primary aim of this review is to summarise their cytogenetic, genomic, immunogenetic, and epigenetic features, with a particular focus on the clonal

Identifiants

pubmed: 35158965
pii: cancers14030697
doi: 10.3390/cancers14030697
pmc: PMC8833447
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

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Auteurs

David Oscier (D)

Department of Haematology, Royal Bournemouth and Christchurch NHS Trust, Bournemouth BH7 7DW, UK.

Kostas Stamatopoulos (K)

Institute of Applied Biosciences, Centre for Research and Technology-Hellas, 57001 Thessaloniki, Greece.

Amatta Mirandari (A)

Cancer Genomics Group, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK.

Jonathan Strefford (J)

Cancer Genomics Group, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK.

Classifications MeSH