MR Fingerprinting-A Radiogenomic Marker for Diffuse Gliomas.

MR fingerprinting T1 and T2 relaxation times brain/central nervous system cancers gliomas quantitative maps

Journal

Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829

Informations de publication

Date de publication:
30 Jan 2022
Historique:
received: 13 12 2021
revised: 22 01 2022
accepted: 28 01 2022
entrez: 15 2 2022
pubmed: 16 2 2022
medline: 16 2 2022
Statut: epublish

Résumé

(1) Background: Advanced MR imaging (MRI) of brain tumors is mainly based on qualitative contrast images. MR Fingerprinting (MRF) offers a novel approach. The purpose of this study was to use MRF-derived T1 and T2 relaxation maps to differentiate diffuse gliomas according to isocitrate dehydrogenase (IDH) mutation. (2) Methods: Twenty-four patients with histologically verified diffuse gliomas (14 IDH-mutant, four 1p/19q-codeleted, 10 IDH-wildtype) were enrolled. MRF T1 and T2 relaxation times were compared to apparent diffusion coefficient (ADC), relative cerebral blood volume (rCBV) within solid tumor, peritumoral edema, and normal-appearing white matter (NAWM), using contrast-enhanced MRI, diffusion-, perfusion-, and susceptibility-weighted imaging. For perfusion imaging, a T2* weighted perfusion sequence with leakage correction was used. Correlations of MRF T1 and T2 times with two established conventional sequences for T1 and T2 mapping were assessed (a fast double inversion recovery-based MR sequence ('MP2RAGE') for T1 quantification and a multi-contrast spin echo-based sequence for T2 quantification). (3) Results: MRF T1 and T2 relaxation times were significantly higher in the IDH-mutant than in IDH-wildtype gliomas within the solid part of the tumor (

Identifiants

pubmed: 35158990
pii: cancers14030723
doi: 10.3390/cancers14030723
pmc: PMC8833555
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Austrian Science Fund FWF
ID : KLI 679
Pays : Austria
Organisme : Austrian Science Fund FWF
ID : KLI 917
Pays : Austria
Organisme : FWF Austrian Science Fund
ID : KPKLI679FW

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Auteurs

Elisabeth Springer (E)

High-Field MR Centre, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, 1090 Vienna, Austria.
Institute of Radiology, Hietzing Hospital, 1130 Vienna, Austria.

Pedro Lima Cardoso (PL)

High-Field MR Centre, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, 1090 Vienna, Austria.

Bernhard Strasser (B)

High-Field MR Centre, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, 1090 Vienna, Austria.

Wolfgang Bogner (W)

High-Field MR Centre, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, 1090 Vienna, Austria.

Matthias Preusser (M)

Division of Oncology, Department of Internal Medicine I, Medical University of Vienna, 1090 Vienna, Austria.

Georg Widhalm (G)

Department of Neurosurgery, Medical University of Vienna, 1090 Vienna, Austria.

Mathias Nittka (M)

Siemens Healthineers, 91052 Erlangen, Germany.

Gregor Koerzdoerfer (G)

Siemens Healthineers, 91052 Erlangen, Germany.

Pavol Szomolanyi (P)

High-Field MR Centre, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, 1090 Vienna, Austria.
Department of Imaging Methods, Institute of Measurement Science, Slovak Academy of Sciences, 84104 Bratislava, Slovakia.

Gilbert Hangel (G)

High-Field MR Centre, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, 1090 Vienna, Austria.
Department of Neurosurgery, Medical University of Vienna, 1090 Vienna, Austria.

Johannes A Hainfellner (JA)

Division of Neuropathology and Neurochemistry, Department of Neurology, Medical University of Vienna, 1090 Vienna, Austria.

Wolfgang Marik (W)

Division of Neuroradiology and Musculoskeletal Radiology, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, 1090 Vienna, Austria.

Siegfried Trattnig (S)

High-Field MR Centre, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, 1090 Vienna, Austria.
Christian Doppler Laboratory for Clinical Molecular MR Imaging, Medical University of Vienna, 1090 Vienna, Austria.

Classifications MeSH