Heterochromatin Protein 1: A Multiplayer in Cancer Progression.
DDR
HP1
cancer
chromatin dynamics
epigenetic reader
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
01 Feb 2022
01 Feb 2022
Historique:
received:
05
01
2022
revised:
28
01
2022
accepted:
29
01
2022
entrez:
15
2
2022
pubmed:
16
2
2022
medline:
16
2
2022
Statut:
epublish
Résumé
Dysregulation of epigenetic mechanisms as well as genomic mutations contribute to the initiation and progression of cancer. In addition to histone code writers, including histone lysine methyltransferase (KMT), and histone code erasers, including histone lysine demethylase (KDM), histone code reader proteins such as HP1 are associated with abnormal chromatin regulation in human diseases. Heterochromatin protein 1 (HP1) recognizes histone H3 lysine 9 methylation and broadly affects chromatin biology, such as heterochromatin formation and maintenance, transcriptional regulation, DNA repair, chromatin remodeling, and chromosomal segregation. Molecular functions of HP1 proteins have been extensively studied, although their exact roles in diseases require further study. Here, we comprehensively review the studies that have revealed the altered expression of HP1 and its functions in tumorigenesis. In particular, the distinctive effects of each HP1 subtype, namely HP1α, HP1β, and HP1γ, have been thoroughly explored in various cancer types. We also highlight how HP1 can serve as a potential biomarker for cancer prognosis and therapeutic target for cancer patients.
Identifiants
pubmed: 35159030
pii: cancers14030763
doi: 10.3390/cancers14030763
pmc: PMC8833910
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : National Research Foundation of Korea
ID : 2018R1A6A1A03023718, 2019R1A2C1008619, and 2019H1A2A1076925
Références
Endocr Rev. 2004 Apr;25(2):276-308
pubmed: 15082523
Biochem Biophys Res Commun. 2018 Jun 7;500(3):691-697
pubmed: 29678579
Cell Div. 2014 Dec 30;9:6
pubmed: 25729403
Transl Oncol. 2018 Oct;11(5):1110-1118
pubmed: 30031230
Mol Cell Biol. 1986 Nov;6(11):3862-72
pubmed: 3099166
Asia Pac J Clin Oncol. 2018 Oct;14(5):e283-e288
pubmed: 29124886
EMBO J. 2000 Apr 3;19(7):1587-97
pubmed: 10747027
J Gastrointest Oncol. 2020 Oct;11(5):932-951
pubmed: 33209489
Cell Death Differ. 2020 Sep;27(9):2537-2551
pubmed: 32203172
Oncogene. 2018 Jan 25;37(4):415-426
pubmed: 28967902
Anticancer Res. 2006 Nov-Dec;26(6B):4349-56
pubmed: 17201154
J Cell Mol Med. 2018 Jun;22(6):3246-3258
pubmed: 29602239
Front Pharmacol. 2018 Oct 16;9:1166
pubmed: 30386240
Oncol Rep. 2014 Jun;31(6):2525-34
pubmed: 24756776
J Biol Chem. 2006 Jul 7;281(27):18668-76
pubmed: 16648629
Cell. 2011 Mar 4;144(5):646-74
pubmed: 21376230
Oncogene. 2016 May 5;35(18):2379-89
pubmed: 26300005
Breast Cancer Res Treat. 1999 May;55(2):127-36
pubmed: 10481940
Nucleic Acids Res. 2003 May 1;31(9):2305-12
pubmed: 12711675
FEBS Open Bio. 2020 Oct;10(10):2206-2215
pubmed: 32894652
Science. 2001 Apr 6;292(5514):110-3
pubmed: 11283354
Cell Death Dis. 2020 Feb 6;11(2):105
pubmed: 32029741
Cell Cycle. 2007 Apr 1;6(7):784-9
pubmed: 17377503
Cancer Res. 2018 Jul 15;78(14):3834-3848
pubmed: 29764865
Nature. 2017 Jul 13;547(7662):236-240
pubmed: 28636604
Nature. 2005 Dec 22;438(7071):1116-22
pubmed: 16222246
Nucleic Acids Res. 2017 Oct 13;45(18):10504-10517
pubmed: 28985346
J Cell Sci. 2005 Nov 1;118(Pt 21):5035-46
pubmed: 16254244
EMBO Mol Med. 2009 Jun;1(3):178-91
pubmed: 20049717
BMC Cancer. 2020 Feb 22;20(1):145
pubmed: 32087696
Sci Rep. 2012;2:584
pubmed: 22900142
J Cell Biol. 2011 Apr 4;193(1):81-95
pubmed: 21464229
Oncogene. 2010 Apr 22;29(16):2357-67
pubmed: 20140018
Cancer Biol Ther. 2007 Jan;6(1):64-9
pubmed: 17172825
Semin Oncol. 1999 Aug;26(4):407-21
pubmed: 10482183
Genes Dev. 2011 Sep 1;25(17):1807-19
pubmed: 21865325
Cell Rep. 2015 Apr 7;11(1):149-63
pubmed: 25818296
Mutat Res. 2008 Dec 1;647(1-2):13-20
pubmed: 18926834
Am J Pathol. 2009 Jan;174(1):309-16
pubmed: 19056850
Oncotarget. 2019 Jul 30;10(46):4743-4760
pubmed: 31413816
J Proteome Res. 2006 Jun;5(6):1460-8
pubmed: 16739997
Cancer Manag Res. 2020 Oct 14;12:10113-10125
pubmed: 33116867
Gastroenterology. 2012 Feb;142(2):388-98.e1-7
pubmed: 22079596
BMC Cancer. 2013 Mar 23;13:148
pubmed: 23522301
Nucleic Acids Res. 2013 Jun;41(11):5784-98
pubmed: 23589625
Cancer Res. 2007 Apr 1;67(7):3239-53
pubmed: 17409432
Int J Mol Sci. 2018 Jun 14;19(6):
pubmed: 29903985
Am J Pathol. 2011 Feb;178(2):672-8
pubmed: 21281799
EMBO J. 1997 May 1;16(9):2473-81
pubmed: 9171360
Curr Biol. 2000 May 4;10(9):517-25
pubmed: 10801440
J Biol Chem. 2012 Apr 13;287(16):13026-39
pubmed: 22318730
Lab Invest. 2014 Jul;94(7):788-95
pubmed: 24840329
Nature. 2008 May 29;453(7195):682-6
pubmed: 18438399
Breast Cancer Res. 2009;11(3):R42
pubmed: 19566924
Nat Rev Mol Cell Biol. 2004 Apr;5(4):296-304
pubmed: 15071554
Front Oncol. 2020 Sep 04;10:582667
pubmed: 33014884
Int J Oncol. 2014 Dec;45(6):2541-8
pubmed: 25201136
PLoS One. 2015 Mar 13;10(3):e0121207
pubmed: 25769025
Oncogene. 2019 Aug;38(31):5971-5986
pubmed: 31253870
PLoS One. 2011 Feb 15;6(2):e17036
pubmed: 21347226
Cancer Res. 2010 Aug 15;70(16):6516-26
pubmed: 20682794
J Leukoc Biol. 2005 Jan;77(1):100-11
pubmed: 15507473
Oncogene. 2019 Jul;38(28):5658-5669
pubmed: 30996246
Cancer Res. 2000 Jul 1;60(13):3359-63
pubmed: 10910038
Oncotarget. 2016 Jan 26;7(4):4695-711
pubmed: 26683361
Mol Cancer Res. 2012 Mar;10(3):401-14
pubmed: 22205726
Oncotarget. 2016 Oct 11;7(41):66525-66539
pubmed: 27167190
Mol Med Rep. 2019 May;19(5):4205-4212
pubmed: 30942427
Nucleic Acids Res. 1991 Feb 25;19(4):789-94
pubmed: 1708124
Chem Biol. 1996 Nov;3(11):895-904
pubmed: 8939708
Aging (Albany NY). 2019 Aug 2;11(15):5483-5497
pubmed: 31375643
Oncotarget. 2017 May 3;8(31):51402-51415
pubmed: 28881656
J Cell Biochem. 2017 Jan;118(1):43-51
pubmed: 27206651
Endocr Relat Cancer. 2010 May 18;17(2):455-67
pubmed: 20308360
Signal Transduct Target Ther. 2019 Dec 17;4:62
pubmed: 31871779
Mol Cell Biol. 2015 Jan;35(2):406-16
pubmed: 25384975
J Neurooncol. 2019 Oct;145(1):35-48
pubmed: 31502042
J Mol Endocrinol. 2013 Apr 23;50(3):401-9
pubmed: 23536649
Int J Radiat Oncol Biol Phys. 2018 Jan 1;100(1):174-187
pubmed: 29107335
Oncogene. 2015 Jan 2;34(1):104-18
pubmed: 24292684
Cancer Res. 2015 Nov 1;75(21):4593-604
pubmed: 26333808
PLoS One. 2020 Feb 6;15(2):e0217452
pubmed: 32027651
PLoS One. 2012;7(8):e41401
pubmed: 22870217
Exp Hematol. 2006 Apr;34(4):453-62
pubmed: 16569592