Equal Efficacy and Safety Profile in Elderly Patients with Hepatocellular Carcinoma Receiving Palliative Treatment.

TACE elderly patients hepatocellular carcinoma palliative treatment sorafenib

Journal

Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829

Informations de publication

Date de publication:
01 Feb 2022
Historique:
received: 16 12 2021
revised: 20 01 2022
accepted: 27 01 2022
entrez: 15 2 2022
pubmed: 16 2 2022
medline: 16 2 2022
Statut: epublish

Résumé

Palliative treatment of elderly patients with hepatocellular carcinoma (HCC) is often challenging due to comorbidities or frailty, and data about the outcome and overall survival (OS) in these patients are limited. This was a retrospective single centre study. Patients were grouped according to their age as young (<60 years; YP), intermediate (60-70 years; IP) or elderly (>70 years; EP). Administration of chemotherapy or transarterial chemoembolization (TACE) was defined as palliative treatment. Therapy-related adverse events (AE) were assessed via CTCAE 5.0. Out of 656 patients analyzed,

Identifiants

pubmed: 35159035
pii: cancers14030768
doi: 10.3390/cancers14030768
pmc: PMC8833746
pii:
doi:

Types de publication

Journal Article

Langues

eng

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Auteurs

Thorben W Fründt (TW)

I. Department of Medicine, Gastroenterology and Hepatology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Christian Casar (C)

Bioinformatics Facility, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Johann von Felden (J)

I. Department of Medicine, Gastroenterology and Hepatology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Ulrike Schöler (U)

I. Department of Medicine, Gastroenterology and Hepatology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Maximilian Priebe (M)

I. Department of Medicine, Gastroenterology and Hepatology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Jenny Kraczyk (J)

Bioinformatics Facility, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Hannes Ahrend (H)

Department of Internal Medicine, Israelitic Hospital, 22297 Hamburg, Germany.

Johannes Salamon (J)

Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Gerhard Adam (G)

Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Samuel Huber (S)

I. Department of Medicine, Gastroenterology and Hepatology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Ansgar W Lohse (AW)

I. Department of Medicine, Gastroenterology and Hepatology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Henning Wege (H)

I. Department of Medicine, Gastroenterology and Hepatology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Cancer Center Esslingen, Klinikum Esslingen, 73730 Esslingen am Neckar, Germany.

Kornelius Schulze (K)

I. Department of Medicine, Gastroenterology and Hepatology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Classifications MeSH