The Role of Decorin Proteoglycan in Mitophagy.
MET
Peg3
VEGFR2
autophagy
mitostatin
small leucine-rich proteoglycans
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
04 Feb 2022
04 Feb 2022
Historique:
received:
24
01
2022
accepted:
02
02
2022
entrez:
15
2
2022
pubmed:
16
2
2022
medline:
16
2
2022
Statut:
epublish
Résumé
Proteoglycans are emerging as critical regulators of intracellular catabolism. This rise in prominence has transformed our basic understanding and alerted us to the existence of non-canonical pathways, independent of nutrient deprivation, that potently control the autophagy downstream of a cell surface receptor. As a member of the small leucine-rich proteoglycan gene family, decorin has single-handedly pioneered the connection between extracellular matrix signaling and autophagy regulation. Soluble decorin evokes protracted endothelial cell autophagy via Peg3 and breast carcinoma cell mitophagy via mitostatin by interacting with VEGFR2 or the MET receptor tyrosine kinase, respectively. In this paper, we give a mechanistic perspective of the vital factors underlying the nutrient-independent, SLRP-dependent programs utilized for autophagic and/or mitophagic progression in breast cancer. Future protein therapies based on decorin (or fellow proteoglycan members) will represent a quantum leap forward in transforming autophagic progression into a powerful tool to control intracellular cell catabolism from the outside.
Identifiants
pubmed: 35159071
pii: cancers14030804
doi: 10.3390/cancers14030804
pmc: PMC8834502
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
J Biol Chem. 2013 Jul 26;288(30):22019-32
pubmed: 23754282
J Cell Mol Med. 2011 Feb;15(2):232-43
pubmed: 20015203
Matrix Biol. 2019 Jan;75-76:1-11
pubmed: 30130584
J Cell Biol. 1997 Feb 10;136(3):729-43
pubmed: 9024701
Cancers (Basel). 2021 Apr 20;13(8):
pubmed: 33924197
Gene Ther. 2015 Mar;22(3):247-56
pubmed: 25503693
J Biol Chem. 2000 Oct 20;275(42):32879-87
pubmed: 10913155
Annu Rev Genet. 2009;43:67-93
pubmed: 19653858
Nature. 2008 Dec 4;456(7222):605-10
pubmed: 19052620
Eur J Biochem. 2004 Aug;271(16):3389-98
pubmed: 15291816
PLoS One. 2012;7(9):e45559
pubmed: 23029096
Nat Metab. 2021 Aug;3(8):1058-1070
pubmed: 34417591
J Biol Chem. 2020 May 1;295(18):6064-6079
pubmed: 32209654
Matrix Biol. 2014 Feb;34:46-54
pubmed: 24472739
Autophagy. 2013 Nov 1;9(11):1801-17
pubmed: 24149440
PLoS One. 2012;7(9):e43669
pubmed: 22984437
Cell. 2019 Jan 10;176(1-2):11-42
pubmed: 30633901
Trends Mol Med. 2009 Jan;15(1):5-13
pubmed: 19091631
Genes Dev. 2015 May 15;29(10):989-99
pubmed: 25995186
Mol Cancer. 2019 Mar 30;18(1):67
pubmed: 30927930
Matrix Biol. 2017 Dec;64:81-93
pubmed: 28882761
FEBS J. 2013 May;280(10):2353-68
pubmed: 23350987
J Cell Biol. 2014 Apr 28;205(2):143-53
pubmed: 24751536
Cell Death Dis. 2018 Feb 28;9(3):330
pubmed: 29491355
Nature. 2012 Jan 11;481(7382):463-8
pubmed: 22237023
J Biol Chem. 1982 Sep 25;257(18):11135-44
pubmed: 7107648
J Cell Biol. 2010 Apr 19;189(2):211-21
pubmed: 20404107
Nature. 1992 Nov 26;360(6402):361-4
pubmed: 1280332
J Intern Med. 2015 Nov;278(5):447-61
pubmed: 26477596
Nat Med. 2001 Feb;7(2):192-8
pubmed: 11175850
J Biol Chem. 2010 Dec 31;285(53):42075-85
pubmed: 20974860
J Cell Sci. 2015 Oct 1;128(19):3525-31
pubmed: 26377767
Dis Model Mech. 2011 Jul;4(4):427-9
pubmed: 21708898
Biochemistry. 2015 Aug 4;54(30):4583-98
pubmed: 26177309
J Clin Invest. 2003 Dec;112(12):1809-20
pubmed: 14638851
Sci Rep. 2017 Jan 10;7:40495
pubmed: 28071719
J Biol Chem. 2002 Sep 20;277(38):35671-81
pubmed: 12105206
J Biol Chem. 2010 Mar 12;285(11):8472-80
pubmed: 20064927
Mol Cells. 2018 Dec 31;41(12):1000-1007
pubmed: 30590907
J Biol Chem. 2000 Jul 21;275(29):21801-4
pubmed: 10823816
Nature. 2014 Jun 5;510(7503):162-6
pubmed: 24784582
Cold Spring Harb Perspect Biol. 2012 Nov 01;4(11):
pubmed: 23125018
Am J Physiol Lung Cell Mol Physiol. 2001 Jun;280(6):L1327-34
pubmed: 11350814
Annu Rev Cell Biol. 1988;4:229-55
pubmed: 3143379
Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):3092-7
pubmed: 10077642
Am J Physiol Cell Physiol. 2021 Aug 1;321(2):C343-C354
pubmed: 34191627
J Biol Chem. 1998 Feb 6;273(6):3121-4
pubmed: 9452417
Cell. 2011 Mar 4;144(5):689-702
pubmed: 21376232
Neuron. 2003 Mar 6;37(5):735-49
pubmed: 12628165
World J Gastroenterol. 2016 Jan 7;22(1):379-93
pubmed: 26755884
Biochem Soc Trans. 1993 May;21(2):123S
pubmed: 8359379
Nat Cell Biol. 2011 Feb;13(2):132-41
pubmed: 21258367
Cells. 2019 May 22;8(5):
pubmed: 31121959
Nat Cell Biol. 2013 Jun;15(6):647-58
pubmed: 23604321
Biochim Biophys Acta. 2015 Apr;1855(2):276-300
pubmed: 25829250
Matrix Biol. 2017 Jan;57-58:285-298
pubmed: 27613501
J Clin Invest. 2021 Nov 15;131(22):
pubmed: 34779410
Matrix Biol. 2014 Apr;35:1-2
pubmed: 24871042
Cell Biol Int. 2002;26(1):109-16
pubmed: 11779227
EMBO J. 2012 Mar 7;31(5):1095-108
pubmed: 22343943
Lab Invest. 1982 Aug;47(2):124-38
pubmed: 7109538
Front Physiol. 2018 Aug 17;9:1129
pubmed: 30174616
Traffic. 2002 Jul;3(7):472-82
pubmed: 12047555
FEBS J. 2010 Oct;277(19):3863
pubmed: 20812984
Cell. 2013 Sep 12;154(6):1269-84
pubmed: 24034250
J Biol Chem. 1999 Feb 19;274(8):4489-92
pubmed: 9988678
Oncogene. 2002 Jul 18;21(31):4765-77
pubmed: 12101415
Science. 2008 Jan 11;319(5860):163-4
pubmed: 18187643
Exp Mol Pathol. 2014 Apr;96(2):149-54
pubmed: 24369267
Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):4176-4181
pubmed: 29610308
Hum Gene Ther. 2015 Dec;26(12):813-25
pubmed: 26467629
Matrix Biol. 2017 May;59:69-79
pubmed: 27476612
Hum Mol Genet. 2011 Oct 1;20(19):3852-66
pubmed: 21752829
Matrix Biol. 2016 Sep;55:7-21
pubmed: 27693454
Matrix Biol Plus. 2020 May 28;6-7:100038
pubmed: 33543032
J Biomech Eng. 2005 Feb;127(1):181-5
pubmed: 15868800
J Biol Chem. 2017 Mar 24;292(12):5055-5069
pubmed: 28174297
Genes Cells. 2001 Mar;6(3):237-47
pubmed: 11260267
PLoS One. 2011 Mar 08;6(3):e16746
pubmed: 21408142
Mol Cell Oncol. 2015 Feb 25;2(3):e975645
pubmed: 27308453
Fam Cancer. 2013 Sep;12(3):367-72
pubmed: 23096221
Antioxidants (Basel). 2020 Sep 01;9(9):
pubmed: 32882839
Biochem J. 1984 Nov 1;223(3):587-97
pubmed: 6439184
Nature. 2008 Feb 28;451(7182):1069-75
pubmed: 18305538
Autophagy. 2015;11(10):1833-48
pubmed: 26325487
Nat Cell Biol. 2010 Sep;12(9):823-30
pubmed: 20811354
Small GTPases. 2018 Mar 4;9(1-2):57-65
pubmed: 28463543
Cardiovasc Res. 2006 Nov 1;72(2):313-21
pubmed: 16950237
Cancer Cell. 2020 Apr 13;37(4):471-484
pubmed: 32289271
EMBO Rep. 2020 Jul 3;21(7):e48192
pubmed: 32337819
Cardiovasc Res. 2008 Jul 15;79(2):208-17
pubmed: 18430751
J Cell Biol. 2008 Dec 1;183(5):795-803
pubmed: 19029340
Cell. 2010 Feb 5;140(3):313-26
pubmed: 20144757
Nat Cell Biol. 2010 Feb;12(2):119-31
pubmed: 20098416
Am J Pathol. 2012 Aug;181(2):380-7
pubmed: 22735579
Am J Pathol. 2014 Aug;184(8):2146-53
pubmed: 24976620
Autophagy. 2013 Oct;9(10):1626-8
pubmed: 23989617
J Biol Chem. 2003 Jul 18;278(29):27312-8
pubmed: 12736244
CA Cancer J Clin. 2021 Jan;71(1):7-33
pubmed: 33433946
Matrix Biol. 2018 Oct;71-72:348-367
pubmed: 29277723
Eur J Endocrinol. 2018 Feb;178(2):145-152
pubmed: 29138241
Cancers (Basel). 2021 Sep 25;13(19):
pubmed: 34638283
J Biol Chem. 2018 Aug 3;293(31):12137-12148
pubmed: 29921586
Autophagy. 2008 Aug;4(6):770-82
pubmed: 18594198
Matrix Biol. 2021 Jun;100-101:173-181
pubmed: 33548399
FEBS Lett. 2004 Aug 13;572(1-3):307-13
pubmed: 15304367
Nat Med. 2019 Jan;25(1):165-175
pubmed: 30617325
Cancer Cell. 2013 Mar 18;23(3):302-15
pubmed: 23477830
Biochem Soc Trans. 2019 Oct 31;47(5):1543-1555
pubmed: 31652436
Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6400-5
pubmed: 23509287
Biochem Biophys Res Commun. 2005 Jul 15;332(4):1162-70
pubmed: 15949467
Cell Rep. 2019 Dec 17;29(12):4053-4068.e6
pubmed: 31851933
Lab Invest. 2000 Dec;80(12):1869-80
pubmed: 11140699
Commun Biol. 2021 Jan 15;4(1):72
pubmed: 33452400
Semin Cancer Biol. 2020 May;62:1-8
pubmed: 31078640
EMBO Mol Med. 2014 Apr;6(4):519-38
pubmed: 24497570
J Biol Chem. 1994 Nov 11;269(45):28270-81
pubmed: 7961765
J Biol Chem. 2014 Jun 6;289(23):16114-28
pubmed: 24737315
J Biol Chem. 2012 Feb 17;287(8):5492-506
pubmed: 22194599
EMBO Rep. 2010 Nov;11(11):854-60
pubmed: 20930847
Matrix Biol. 2018 Oct;71-72:1-9
pubmed: 29625183
Matrix Biol. 2015 Oct;48:14-25
pubmed: 26344480
J Cell Mol Med. 2011 May;15(5):1013-31
pubmed: 21155971
FEBS J. 2017 Jan;284(1):10-26
pubmed: 27860287
Br J Pharmacol. 2019 Jan;176(1):5-15
pubmed: 29488209
Biochem J. 1980 Jun 1;187(3):887-91
pubmed: 7188429
J Clin Invest. 2006 Mar;116(3):615-22
pubmed: 16511594
FEBS J. 2007 Aug;274(16):4246-55
pubmed: 17651433
Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):E2582-91
pubmed: 23798385
J Biol Chem. 2014 Feb 21;289(8):4952-68
pubmed: 24403067
J Biol Chem. 2017 Sep 29;292(39):16211-16220
pubmed: 28798237
Autophagy. 2011 Nov;7(11):1379-81
pubmed: 21785263
Methods Mol Biol. 2019;1952:157-191
pubmed: 30825174
Blood. 1994 Dec 1;84(11):3715-23
pubmed: 7949127
Carcinogenesis. 2012 Feb;33(2):326-30
pubmed: 22159220
G3 (Bethesda). 2020 Jan 7;10(1):129-141
pubmed: 31672849
Cancer Metab. 2015 Mar 26;3:4
pubmed: 25810907
Lab Invest. 1995 Aug;73(2):157-60
pubmed: 7637316
PLoS One. 2010 Apr 07;5(4):e10054
pubmed: 20383334
Science. 2013 Apr 26;340(6131):471-5
pubmed: 23620051
Curr Opin Cell Biol. 2017 Apr;45:83-91
pubmed: 28437683
Biotechnol Lett. 2020 Apr;42(4):657-668
pubmed: 31989342
Matrix Biol. 2018 Oct;71-72:396-420
pubmed: 29499356
Matrix Biol. 2019 Jan;75-76:260-270
pubmed: 29080840
Nat Rev Drug Discov. 2012 Sep;11(9):709-30
pubmed: 22935804
Matrix Biol. 2015 Oct;48:6-13
pubmed: 26462577
J Clin Med. 2021 Nov 26;10(23):
pubmed: 34884232
Nat Genet. 1996 Feb;12(2):186-90
pubmed: 8563758
Hum Mol Genet. 2011 May 1;20(9):1726-37
pubmed: 21296869
Nature. 1990 Jul 19;346(6281):281-4
pubmed: 2374594
Matrix Biol. 2018 Aug;68-69:589-601
pubmed: 29382609
PLoS One. 2011 May 06;6(5):e19771
pubmed: 21573075
Biochim Biophys Acta. 2014 Aug;1840(8):2549-59
pubmed: 24582970
Antioxid Redox Signal. 2008 Mar;10(3):621-33
pubmed: 18092941
Semin Cell Dev Biol. 2020 Feb;98:129-138
pubmed: 31154012
Nat Cell Biol. 2013 Jul;15(7):741-50
pubmed: 23685627
J Histochem Cytochem. 1990 Nov;38(11):1549-63
pubmed: 2212616
Science. 2011 Jun 17;332(6036):1429-33
pubmed: 21617040
Nature. 1999 Dec 9;402(6762):672-6
pubmed: 10604474
Matrix Biol. 2016 Jan;49:10-24
pubmed: 26163349
Nat Rev Mol Cell Biol. 2018 Feb;19(2):121-135
pubmed: 28974774
Nephrol Dial Transplant. 2009 Jul;24(7):2044-51
pubmed: 19144998
Trends Biochem Sci. 2011 Jan;36(1):30-8
pubmed: 20728362
J Biol Chem. 2012 Nov 23;287(48):40652-60
pubmed: 23060438
Chem Rev. 2018 Sep 26;118(18):9152-9232
pubmed: 30204432
Mol Biol Cell. 2009 Apr;20(7):1992-2003
pubmed: 19225151
Oncogene. 2009 Jan 15;28(2):257-69
pubmed: 18931701
Int J Mol Sci. 2021 Jul 17;22(14):
pubmed: 34299278
J Biol Chem. 2009 May 15;284(20):13843-13855
pubmed: 19279012
J Biol Chem. 2012 Oct 5;287(41):33926-33
pubmed: 22879588
Nat Rev Mol Cell Biol. 2013 May;14(5):283-96
pubmed: 23609508
Nat Rev Cancer. 2001 Oct;1(1):46-54
pubmed: 11900251
Circ Res. 2011 Oct 28;109(10):1153-61
pubmed: 21921267
Adv Drug Deliv Rev. 2016 Feb 1;97:174-85
pubmed: 26522384
J Biol Chem. 2004 Feb 20;279(8):6606-12
pubmed: 14660661
Matrix Biol. 2015 Mar;42:11-55
pubmed: 25701227
Biochem Biophys Res Commun. 2014 Jul 25;450(2):1089-94
pubmed: 24996176
Nat Rev Cancer. 2003 Jun;3(6):401-10
pubmed: 12778130
Matrix Biol. 2015 Oct;48:26-35
pubmed: 26319110
J Biomech Eng. 2004 Apr;126(2):252-7
pubmed: 15179856
Matrix Biol. 2021 Jun;100-101:162-172
pubmed: 33373668
Front Neurosci. 2020 Jun 16;14:527
pubmed: 32612495
Genes Dev. 2005 Jun 15;19(12):1466-73
pubmed: 15964996
Science. 2012 Nov 16;338(6109):956-9
pubmed: 23112296
J Clin Invest. 2005 May;115(5):1163-76
pubmed: 15841211
J Biol Chem. 2007 Dec 7;282(49):35887-98
pubmed: 17942398
Cell Mol Life Sci. 2021 Apr;78(8):3817-3851
pubmed: 33580835
Carcinogenesis. 2008 Jul;29(7):1435-40
pubmed: 18550571
J Biol Chem. 2015 Dec 11;290(50):29742-57
pubmed: 26494620
Mol Cell Biol. 2012 Jan;32(1):2-11
pubmed: 22025673
EMBO J. 2020 Sep 15;39(18):e105826
pubmed: 33433003
Cell Tissue Res. 2015 Sep;361(3):833-44
pubmed: 25715761
Oncotarget. 2017 Dec 11;9(1):995-1011
pubmed: 29416672
Autophagy. 2013 Nov 1;9(11):1758-69
pubmed: 24121706
Cancer Immunol Res. 2016 Jun;4(6):520-30
pubmed: 27068336
Cancer Cell. 2013 Mar 18;23(3):287-301
pubmed: 23416000