Leukocyte Telomere Length Correlates with Extended Female Fertility.
female fertility
longevity
reproductive aging
telomeres
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
02 02 2022
02 02 2022
Historique:
received:
18
12
2021
revised:
23
01
2022
accepted:
31
01
2022
entrez:
15
2
2022
pubmed:
16
2
2022
medline:
9
4
2022
Statut:
epublish
Résumé
Current social trends of delayed reproduction to the fourth and fifth decade of life call for a better understanding of reproductive aging. Demographic studies correlated late reproduction with general health and longevity. Telomeres, the protective ends of eukaryotic chromosomes, were implicated in various aging-associated pathologies and longevity. To examine whether telomeres are also associated with reproductive aging, we measured by Southern analysis the terminal restriction fragments (TRF) in leukocytes of women delivering a healthy infant following a spontaneous pregnancy at 43-48 years of age. We compared them to age-matched previously fertile women who failed to conceive above age 41. The average TRF length in the extended fertility group (9350 bp) was significantly longer than in the normal fertility group (8850 bp;
Identifiants
pubmed: 35159322
pii: cells11030513
doi: 10.3390/cells11030513
pmc: PMC8834216
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Israel Science Foundation
ID : 2107/18
Organisme : Mirsky fund SZMC
ID : Mirsky fund SZMC
Organisme : Kamla fund, HUJI
ID : Kamla fund, HUJI
Organisme : Israel-UK-Palestine GROWTH Fellowship Scheme, the British Council
ID : Israel-UK-Palestine GROWTH Fellowship Scheme, the British Council
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