Mechanisms of Choice in X-Chromosome Inactivation.

Animals Dosage Compensation, Genetic Female Mammals / genetics Marsupialia / genetics Placenta Pregnancy X Chromosome / genetics X Chromosome Inactivation / genetics
X-chromosome inactivation allelic choice marsupials placentals skewing

Journal

Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052

Informations de publication

Date de publication:
03 02 2022
Historique:
received: 17 12 2021
revised: 30 01 2022
accepted: 31 01 2022
entrez: 15 2 2022
pubmed: 16 2 2022
medline: 9 4 2022
Statut: epublish

Résumé

Early in development, placental and marsupial mammals harbouring at least two X chromosomes per nucleus are faced with a choice that affects the rest of their lives: which of those X chromosomes to transcriptionally inactivate. This choice underlies phenotypical diversity in the composition of tissues and organs and in their response to the environment, and can determine whether an individual will be healthy or affected by an X-linked disease. Here, we review our current understanding of the process of choice during X-chromosome inactivation and its implications, focusing on the strategies evolved by different mammalian lineages and on the known and unknown molecular mechanisms and players involved.

Identifiants

DOI: 10.3390/cells11030535 PMID: 35159344 PMC: PMC8833938
pubmed: 35159344
pii: cells11030535
doi: 10.3390/cells11030535
pmc: PMC8833938
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : European Molecular Biology Organization
ID : EMBO ALTF 1132-2018
Organisme : Marie Skłodowska-Curie Actions
ID : COFUND 664726

Commentaires et corrections

Type : ErratumIn

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Auteurs

Giulia Furlan (G)

Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK.
Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK.

Rafael Galupa (R)

European Molecular Biology Laboratory, Developmental Biology Unit, 69117 Heidelberg, Germany.
ORCID: 0000-0001-7319-043X

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Mechanisms of Choice in X-Chromosome Inactivation.
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Compensation de dosage génétique › Mechanisms of Choice in X-Chromosome Inactivation.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Mechanisms of Choice in X-Chromosome Inactivation.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Marsupialia › Mechanisms of Choice in X-Chromosome Inactivation.
questionsmedicales.fr › Structures de l'embryon › Placenta › Mechanisms of Choice in X-Chromosome Inactivation.
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Mechanisms of Choice in X-Chromosome Inactivation.
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Chromosomes › Chromosomes sexuels › Chromosome X › Mechanisms of Choice in X-Chromosome Inactivation.
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Compensation de dosage génétique › Inactivation du chromosome X › Mechanisms of Choice in X-Chromosome Inactivation.