Prognostic Impact of CD36 Immunohistochemical Expression in Patients with Muscle-Invasive Bladder Cancer Treated with Cystectomy and Adjuvant Chemotherapy.
CD36
MIBC
adjuvant chemotherapy
bladder cancer
fatty acid
lipid metabolism
prognostic biomarker
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
19 Jan 2022
19 Jan 2022
Historique:
received:
10
12
2021
revised:
17
01
2022
accepted:
18
01
2022
entrez:
15
2
2022
pubmed:
16
2
2022
medline:
16
2
2022
Statut:
epublish
Résumé
Neoadjuvant chemotherapy followed by a cystectomy is the standard treatment in muscle-invasive bladder cancer (MIBC). However, the role of chemotherapy in the adjuvant setting remains controversial, and therefore new prognostic and predictive biomarkers are needed to improve the selection of MIBC patients. While lipid metabolism has been related to several biological processes in many tumours, including bladder cancer, no metabolic biomarkers have been identified as prognostic in routine clinical practice. In this multicentre, retrospective study of 198 patients treated with cystectomy followed by platinum-based adjuvant chemotherapy, we analysed the immunohistochemical expression of CD36 and correlated our findings with clinicopathological characteristics and survival. CD36 immunostaining was positive in 30 patients (15%) and associated with more advanced pathologic stages (pT3b-T4;
Identifiants
pubmed: 35159947
pii: jcm11030497
doi: 10.3390/jcm11030497
pmc: PMC8836680
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Asociación Española Contra el Cáncer
ID : Grant Grupos coordinados estables de investigación 2014
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