Spectrum of Kidney Disorders Associated with T-Cell Immunoclones.
STAT3
T-cell receptor
autoimmune disorders
immunoclones
large granular lymphocytic leukemia
renal fibrosis
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
25 Jan 2022
25 Jan 2022
Historique:
received:
15
12
2021
revised:
21
01
2022
accepted:
24
01
2022
entrez:
15
2
2022
pubmed:
16
2
2022
medline:
16
2
2022
Statut:
epublish
Résumé
Large granular T-cell leukemia is a clonal hematological condition often associated with autoimmune disorders. Whether small-sized T-cell clones that are otherwise asymptomatic can promote immune kidney disorders remains elusive. In this monocentric retrospective cohort in a tertiary referral center in France, we reviewed characteristics of 29 patients with T-cell clone proliferation and autoimmune kidney disorders. Next-generation sequencing of the T-cell receptor of circulating T-cells was performed in a subset of patients. The T-cell clones were detected owing to systematic screening (mean count 0.32 × 10
Identifiants
pubmed: 35160055
pii: jcm11030604
doi: 10.3390/jcm11030604
pmc: PMC8836922
pii:
doi:
Types de publication
Journal Article
Langues
eng
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