The Role of Topical Povidone-Iodine in the Management of Infectious Keratitis: A Pilot Study.
PVP-I
corneal swab
infectious keratitis
personalized therapy
time-to-result for pathogen identification
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
05 Feb 2022
05 Feb 2022
Historique:
received:
30
12
2021
revised:
29
01
2022
accepted:
02
02
2022
entrez:
15
2
2022
pubmed:
16
2
2022
medline:
16
2
2022
Statut:
epublish
Résumé
The aim of this prospective explorative study was to evaluate the safety and the effectiveness of topical polyvinylpyrrolidone-iodine (PVP-I) administered during the time-to-results period for pathogen identification and susceptibility testing in patients with infectious keratitis (IK). A corneal swab (CS) for antimicrobial evaluation was performed at enrollment (T0) and topical 0.66%-PVP-I was administered until the laboratory results were available (T1). Ulcer and infiltrate areas and infiltrate depths were compared between T0 and T1 (i.e., time-to-result period). Patients were then shifted to a specific antimicrobial therapy and followed up until resolution of their infiltrates (Tlast-TL). Twenty-five eyes were enrolled, and none showed clinical worsening leading to protocol withdrawal. At T1, ulcer and infiltrate areas showed significant improvement in Gram-positive IK (
Identifiants
pubmed: 35160298
pii: jcm11030848
doi: 10.3390/jcm11030848
pmc: PMC8837158
pii:
doi:
Types de publication
Journal Article
Langues
eng
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