Magnesium-Based Alloys Used in Orthopedic Surgery.
Mg-based alloys
biocompatibility
biomaterials
clinical translation
mechanical properties
orthopedy
Journal
Materials (Basel, Switzerland)
ISSN: 1996-1944
Titre abrégé: Materials (Basel)
Pays: Switzerland
ID NLM: 101555929
Informations de publication
Date de publication:
02 Feb 2022
02 Feb 2022
Historique:
received:
18
12
2021
revised:
27
01
2022
accepted:
29
01
2022
entrez:
15
2
2022
pubmed:
16
2
2022
medline:
16
2
2022
Statut:
epublish
Résumé
Magnesium (Mg)-based alloys have become an important category of materials that is attracting more and more attention due to their high potential use as orthopedic temporary implants. These alloys are a viable alternative to nondegradable metals implants in orthopedics. In this paper, a detailed overview covering alloy development and manufacturing techniques is described. Further, important attributes for Mg-based alloys involved in orthopedic implants fabrication, physiological and toxicological effects of each alloying element, mechanical properties, osteogenesis, and angiogenesis of Mg are presented. A section detailing the main biocompatible Mg-based alloys, with examples of mechanical properties, degradation behavior, and cytotoxicity tests related to in vitro experiments, is also provided. Special attention is given to animal testing, and the clinical translation is also reviewed, focusing on the main clinical cases that were conducted under human use approval.
Identifiants
pubmed: 35161092
pii: ma15031148
doi: 10.3390/ma15031148
pmc: PMC8840615
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : This work was supported by a grant of the Romanian Ministry of Education and Research, CNCS-UEFISCDI, Project number PN-III-P4-ID-PCE-2020-2591, within PNCDI III. Also, financial support from the Competitiveness Operational Program 2014-2020, Action 1.1.3
ID : PN-III-P4-ID-PCE-2020-2591 and 250/11.05.2020
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