Do We Have Viable Protective Strategies against Anesthesia-Induced Developmental Neurotoxicity?
ROS
mitochondria
neonatal anesthesia
neuroactive steroids
neuroprotection
neurotoxicity
signaling pathways
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
20 Jan 2022
20 Jan 2022
Historique:
received:
31
12
2021
revised:
14
01
2022
accepted:
18
01
2022
entrez:
15
2
2022
pubmed:
16
2
2022
medline:
11
3
2022
Statut:
epublish
Résumé
Since its invention, general anesthesia has been an indispensable component of modern surgery. While traditionally considered safe and beneficial in many pathological settings, hundreds of preclinical studies in various animal species have raised concerns about the detrimental and long-lasting consequences that general anesthetics may cause to the developing brain. Clinical evidence of anesthetic neurotoxicity in humans continues to mount as we continue to contemplate how to move forward. Notwithstanding the alarming evidence, millions of children are being anesthetized each year, setting the stage for substantial healthcare burdens in the future. Hence, furthering our knowledge of the molecular underpinnings of anesthesia-induced developmental neurotoxicity is crucially important and should enable us to develop protective strategies so that currently available general anesthetics could be safely used during critical stages of brain development. In this mini-review, we provide a summary of select strategies with primary focus on the mechanisms of neuroprotection and potential for clinical applicability. First, we summarize a diverse group of chemicals with the emphasis on intracellular targets and signal-transduction pathways. We then discuss epigenetic and transgenerational effects of general anesthetics and potential remedies, and also anesthesia-sparing or anesthesia-delaying approaches. Finally, we present evidence of a novel class of anesthetics with a distinct mechanism of action and a promising safety profile.
Identifiants
pubmed: 35163060
pii: ijms23031128
doi: 10.3390/ijms23031128
pmc: PMC8834847
pii:
doi:
Substances chimiques
Anesthetics
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NICHD NIH HHS
ID : R01 HD097990
Pays : United States
Organisme : NIH HHS
ID : R01 GM123746; R01 HD097990; R01 HD044517; R01 HD044517-S; R01 GM118197; R01 GM118197-S1
Pays : United States
Organisme : Department of Anesthesiology at the University of Colorado Anschutz Medical campus
ID : CU Medicine Endowment to VJT
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