Predominant Role of mTOR Signaling in Skin Diseases with Therapeutic Potential.
acne
atopic dermatitis
cutaneous T cell lymphoma
inhibitors
mTOR signaling pathway
melanoma
pemphigus
psoriasis
therapy
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
01 Feb 2022
01 Feb 2022
Historique:
received:
28
12
2021
revised:
30
01
2022
accepted:
31
01
2022
entrez:
15
2
2022
pubmed:
16
2
2022
medline:
31
3
2022
Statut:
epublish
Résumé
The serine/threonine kinase mechanistic target of rapamycin (mTOR) plays a pivotal role in the regulation of cell proliferation, survival, and motility in response to availability of energy and nutrients as well as mitogens. The mTOR signaling axis regulates important biological processes, including cellular growth, metabolism, and survival in many tissues. In the skin, dysregulation of PI3K/AKT/mTOR pathway may lead to severe pathological conditions characterized by uncontrolled proliferation and inflammation, including skin hyperproliferative as well as malignant diseases. Herein, we provide an update on the current knowledge regarding the pathogenic implication of the mTOR pathway in skin diseases with inflammatory features (such as psoriasis, atopic dermatitis, pemphigus, and acne) and malignant characteristics (such as cutaneous T cell lymphoma and melanoma) while we critically discuss current and future perspectives for therapeutic targeting of mTOR axis in clinical practice.
Identifiants
pubmed: 35163615
pii: ijms23031693
doi: 10.3390/ijms23031693
pmc: PMC8835793
pii:
doi:
Substances chimiques
MTOR protein, human
EC 2.7.1.1
TOR Serine-Threonine Kinases
EC 2.7.11.1
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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