The Proteolysis of ECM in Intervertebral Disc Degeneration.
ECM
IDD
protease
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
02 Feb 2022
02 Feb 2022
Historique:
received:
13
12
2021
revised:
28
01
2022
accepted:
29
01
2022
entrez:
15
2
2022
pubmed:
16
2
2022
medline:
8
3
2022
Statut:
epublish
Résumé
Intervertebral disc (IVD) degeneration (IDD) is a pathological process that commonly occurs throughout the human life span and is a major cause of lower back pain. Better elucidation of the molecular mechanisms involved in disc degeneration could provide a theoretical basis for the development of lumbar disc intervention strategies. In recent years, extracellular matrix (ECM) homeostasis has received much attention due to its relevance to the mechanical properties of IVDs. ECM proteolysis mediated by a variety of proteases is involved in the pathological process of disc degeneration. Here, we discuss in detail the relationship between the IVD as well as the ECM and the role of ECM proteolysis in the degenerative process of the IVD. Targeting ECM proteolysis-associated proteases may be an effective means of intervention in IDD.
Identifiants
pubmed: 35163637
pii: ijms23031715
doi: 10.3390/ijms23031715
pmc: PMC8835917
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Natural Science Foundation of China
ID : 81902261
Organisme : National Natural Science Foundation of China
ID : 81772401
Organisme : National Natural Science Foundation of China
ID : 82002366
Organisme : the Application Foundation and Advanced Program of Wuhan Science and Technolo-gy Bureau
ID : 2019020701011457
Organisme : the Fundamental Research Funds for the Central Universities
ID : 2019kfyXMBZ063
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