Interaction of Alpha Synuclein and Microtubule Organization Is Linked to Impaired Neuritic Integrity in Parkinson's Patient-Derived Neuronal Cells.
Parkinson’s disease
SNCA duplication
alpha-synuclein
iPSC
microtubule
neurite
neurodegeneration
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
05 Feb 2022
05 Feb 2022
Historique:
received:
29
12
2021
revised:
02
02
2022
accepted:
03
02
2022
entrez:
15
2
2022
pubmed:
16
2
2022
medline:
9
4
2022
Statut:
epublish
Résumé
Parkinson's disease (PD) is neuropathologically characterized by the loss of dopaminergic neurons and the deposition of aggregated alpha synuclein (aSyn). Mounting evidence suggests that neuritic degeneration precedes neuronal loss in PD. A possible underlying mechanism could be the interference of aSyn with microtubule organization in the neuritic development, as implied by several studies using cell-free model systems. In this study, we investigate the impact of aSyn on microtubule organization in aSyn overexpressing H4 neuroglioma cells and midbrain dopaminergic neuronal cells (mDANs) generated from PD patient-derived human induced pluripotent stem cells (hiPSCs) carrying an aSyn gene duplication (
Identifiants
pubmed: 35163733
pii: ijms23031812
doi: 10.3390/ijms23031812
pmc: PMC8836605
pii:
doi:
Substances chimiques
SNCA protein, human
0
Tubulin
0
alpha-Synuclein
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : the Interdisciplinary Center for Clinical Research of the University Hospital Erlangen, Germany
ID : advanced project E30
Organisme : Deutsche Forschungsgemeinschaft
ID : 270949263/GRK2162, WI 3567/2-1, 125440785/SFB877 project B11 and Z2
Organisme : Bavarian Research Consortium "Interaction of Human Brain Cells" (ForInter)
ID : ForInter
Organisme : Fritz Thyssen Foundation
ID : 10.19.2.024MN to IP
Organisme : the Bundesministerium für Bildung und Forschung, Germany (BMBF, HitTau)
ID : 01EK1605B
Références
Sci Rep. 2019 Jan 24;9(1):544
pubmed: 30679445
Mov Disord. 2019 Oct;34(10):1406-1422
pubmed: 31483900
Brain. 2013 Aug;136(Pt 8):2419-31
pubmed: 23884810
Exp Neurol. 2020 Dec;334:113466
pubmed: 32949572
Sci Rep. 2017 Feb 22;7:42942
pubmed: 28224980
Nat Neurosci. 2019 Jul;22(7):1099-1109
pubmed: 31235907
Ann Neurol. 1990 Apr;27(4):373-85
pubmed: 1972319
Neurobiol Dis. 2015 May;77:276-83
pubmed: 25046996
Neuropsychiatr Dis Treat. 2018 Jun 27;14:1685-1695
pubmed: 29983568
Cell Stem Cell. 2018 Jul 05;23(1):123-131.e6
pubmed: 29979986
Autophagy. 2014;10(12):2171-92
pubmed: 25484190
Nat Commun. 2021 Jun 21;12(1):3817
pubmed: 34155194
Proc Natl Acad Sci U S A. 2016 Jun 7;113(23):6544-9
pubmed: 27140603
Autophagy. 2018;14(1):98-119
pubmed: 29198173
Science. 2012 Nov 16;338(6109):949-53
pubmed: 23161999
Sci Rep. 2016 Sep 15;6:33289
pubmed: 27628239
Cell. 2011 Jul 8;146(1):37-52
pubmed: 21700325
J Clin Invest. 2014 Mar;124(3):1340-9
pubmed: 24531549
J Parkinsons Dis. 2018;8(4):479-493
pubmed: 30149462
Front Cell Neurosci. 2016 Dec 22;10:293
pubmed: 28066188
Brain Sci. 2021 Mar 14;11(3):
pubmed: 33799491
Front Neurosci. 2017 Sep 04;11:451
pubmed: 28928628
Neuron. 2022 Feb 2;110(3):436-451.e11
pubmed: 34793693
Mol Biol Cell. 2009 Aug;20(16):3725-39
pubmed: 19553474
Acta Neuropathol. 2021 Jul;142(1):87-115
pubmed: 33978813
Nature. 1997 Aug 28;388(6645):839-40
pubmed: 9278044
Cell Death Dis. 2015 Jul 09;6:e1811
pubmed: 26158517
Neurobiol Aging. 2003 Mar-Apr;24(2):197-211
pubmed: 12498954
Mol Neurodegener. 2018 May 11;13(1):21
pubmed: 29751824
Nat Rev Mol Cell Biol. 2020 Jun;21(6):307-326
pubmed: 32107477
J Neural Transm (Vienna). 2003 May;110(5):517-36
pubmed: 12721813
Nat Clin Pract Neurol. 2006 Mar;2(3):136-46
pubmed: 16932540
PLoS One. 2013;8(3):e59252
pubmed: 23533608
Neurochem Res. 2007 Aug;32(8):1387-98
pubmed: 17406983
Cell Death Dis. 2015 Nov 26;6:e1994
pubmed: 26610207
Proc Natl Acad Sci U S A. 2015 Sep 22;112(38):E5308-17
pubmed: 26324905
Nat Rev Neurol. 2013 Jan;9(1):13-24
pubmed: 23183883
Ann Neurol. 2012 Oct;72(4):517-24
pubmed: 23109146
Hum Mol Genet. 2014 May 15;23(10):2527-41
pubmed: 24381312
Cold Spring Harb Perspect Med. 2012 Jan;2(1):a008888
pubmed: 22315721
Nature. 2018 May;557(7706):558-563
pubmed: 29743672
Neurobiol Dis. 2020 Dec;146:105086
pubmed: 32971232
Nature. 2020 Feb;578(7794):273-277
pubmed: 32025029
J Neurosci. 1988 Aug;8(8):2804-15
pubmed: 3411354
Brain. 2012 Jul;135(Pt 7):2058-73
pubmed: 22719003
Biol Chem. 2019 Aug 27;400(9):1099-1112
pubmed: 31256059
Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):7813-7818
pubmed: 29991596
Hum Mol Genet. 2020 May 8;29(7):1180-1191
pubmed: 32160287
Int J Mol Sci. 2021 Aug 03;22(15):
pubmed: 34361100
J Biol Chem. 2013 Jul 26;288(30):21742-54
pubmed: 23744071
Exp Neurol. 2013 Aug;246:72-83
pubmed: 22285449