Preliminary Studies of Antimicrobial Activity of New Synthesized Hybrids of 2-Thiohydantoin and 2-Quinolone Derivatives Activated with Blue Light.

Anti-Bacterial Agents / chemical synthesis Antifungal Agents Gram-Negative Bacteria / drug effects Gram-Positive Bacteria / drug effects Light Microbial Sensitivity Tests Molecular Structure Phenalenes / pharmacology Pseudomonas aeruginosa Quinolones / chemistry Structure-Activity Relationship Thiohydantoins / chemistry
antibacterial test activity blue light activation hybrid of 2-thiohydantoin and 2-quinolone derivative singlet oxygen generation

Journal

Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009

Informations de publication

Date de publication:
05 Feb 2022
Historique:
received: 27 09 2021
revised: 14 01 2022
accepted: 02 02 2022
entrez: 15 2 2022
pubmed: 16 2 2022
medline: 19 2 2022
Statut: epublish

Résumé

Thiohydantoin and quinolone derivatives have attracted researchers' attention because of a broad spectrum of their medical applications. The aim of our research was to synthesize and analyze the antimicrobial properties of novel 2-thiohydantoin and 2-quinolone derivatives. For this purpose, two series of hybrid compounds were synthesized. Both series consisted of 2-thiohydantoin core and 2-quinolone derivative ring, however one of them was enriched with an acetic acid group at N3 atom in 2-thiohydantoin core. Antibacterial properties of these compounds were examined against bacteria:

Identifiants

DOI: 10.3390/molecules27031069 PMID: 35164334 PMC: PMC8839260
pubmed: 35164334
pii: molecules27031069
doi: 10.3390/molecules27031069
pmc: PMC8839260
pii:
doi:

Substances chimiques

Anti-Bacterial Agents 0
Antifungal Agents 0
Phenalenes 0
Quinolones 0
Thiohydantoins 0
phenalen-1-one 548-39-0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Pedagogical University of Kraków
ID : BN.610-519/PBU/2020

Références

J Antimicrob Chemother. 2005 Aug;56(2):324-30
pubmed: 15983029
J Med Chem. 2013 Nov 14;56(21):8389-403
pubmed: 24083834
J Photochem Photobiol B. 2016 May;158:122-9
pubmed: 26971277
Drug Resist Updat. 2012 Aug;15(4):223-36
pubmed: 22846406
Bioorg Med Chem Lett. 2015 Sep 1;25(17):3601-5
pubmed: 26174555
J Med Chem. 2002 Jun 6;45(12):2543-55
pubmed: 12036363
Saudi Pharm J. 2018 May;26(4):568-577
pubmed: 29844729
J Antimicrob Chemother. 1993 Aug;32(2):195-213
pubmed: 8226422
Anal Chem Insights. 2007 Nov 11;2:111-8
pubmed: 19662185
Proc Natl Acad Sci U S A. 2007 Apr 24;104(17):7223-8
pubmed: 17431036
Front Microbiol. 2020 Feb 21;11:283
pubmed: 32153551
J Org Chem. 2006 Mar 17;71(6):2507-9
pubmed: 16526805
Br J Cancer. 1999 May;80(3-4):360-3
pubmed: 10408838
Medchemcomm. 2019 Jun 28;10(10):1719-1739
pubmed: 31803393
J Phys Chem A. 2007 Jul 5;111(26):5756-67
pubmed: 17564419
Virulence. 2017 Aug 18;8(6):938-958
pubmed: 27763824
J Photochem Photobiol B. 2020 Jan;202:111701
pubmed: 31759194
J Photochem Photobiol B. 1996 Feb;32(3):159-64
pubmed: 8622179
Molecules. 2020 Jul 04;25(13):
pubmed: 32635479
J Photochem Photobiol B. 2020 Mar;204:111787
pubmed: 31958676
Am Fam Physician. 2002 Feb 1;65(3):455-64
pubmed: 11858629
ACS Med Chem Lett. 2017 Jul 10;8(8):886-891
pubmed: 28835807
Photochem Photobiol. 1994 Mar;59(3):284-9
pubmed: 8016206
Proc Natl Acad Sci U S A. 1987 May;84(9):2999-3003
pubmed: 3033673
Photochem Photobiol. 1998 Apr;67(4):399-403
pubmed: 9559584
Photomed Laser Surg. 2013 Nov;31(11):554-62
pubmed: 24138193
J Photochem Photobiol B. 1996 Sep;35(3):149-57
pubmed: 8933721
J Photochem Photobiol B. 2008 Aug 21;92(2):83-90
pubmed: 18562206
J Photochem Photobiol B. 1996 Feb;32(3):153-7
pubmed: 8622178
Science. 1994 Apr 15;264(5157):382-8
pubmed: 8153625
Free Radic Biol Med. 2010 Jul 1;49(1):9-21
pubmed: 20363317
Photochem Photobiol. 1991 Nov;54(5):659
pubmed: 1798741
Antimicrob Agents Chemother. 2013 Mar;57(3):1238-45
pubmed: 23262998
Biochemistry. 2014 Mar 18;53(10):1565-74
pubmed: 24576155
ACS Comb Sci. 2017 Aug 14;19(8):555-563
pubmed: 28723092
Adv Exp Med Biol. 2020;1282:37-69
pubmed: 31515709
Antimicrob Agents Chemother. 1989 Nov;33(11):1831-6
pubmed: 2692513
Pharmaceutics. 2021 Apr 21;13(5):
pubmed: 33919271
Ann N Y Acad Sci. 2015 Sep;1354:12-31
pubmed: 26190223
Molecules. 2016 Jul 14;21(7):
pubmed: 27428939
Eur J Med Chem. 2019 Feb 15;164:517-545
pubmed: 30622025
Front Med (Lausanne). 2021 May 12;8:642609
pubmed: 34055830

Auteurs

Agnieszka Kania (A)

Institute of Biology, Pedagogical University of Krakow, Podchorążych 2, 30-084 Kraków, Poland.
ORCID: 0000-0003-2986-0592

Waldemar Tejchman (W)

Institute of Biology, Pedagogical University of Krakow, Podchorążych 2, 30-084 Kraków, Poland.
ORCID: 0000-0001-8336-4288

Anna M Pawlak (AM)

Department of Biophysics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Kraków, Poland.
ORCID: 0000-0002-2911-6125

Krystian Mokrzyński (K)

Department of Biophysics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Kraków, Poland.
ORCID: 0000-0001-8092-9132

Bartosz Różanowski (B)

Institute of Biology, Pedagogical University of Krakow, Podchorążych 2, 30-084 Kraków, Poland.
ORCID: 0000-0002-6362-1758

Bogdan M Musielak (BM)

Department of Organic Chemistry, Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Kraków, Poland.
ORCID: 0000-0002-1665-5920

Magdalena Greczek-Stachura (M)

Institute of Biology, Pedagogical University of Krakow, Podchorążych 2, 30-084 Kraków, Poland.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Preliminary Studies of Antimicrobial Activity...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antifongiques › Preliminary Studies of Antimicrobial Activity...
questionsmedicales.fr › Bactéries › Bactéries à Gram négatif › Preliminary Studies of Antimicrobial Activity...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Preliminary Studies of Antimicrobial Activity...
questionsmedicales.fr › Phénomènes physiques › Rayonnement › Rayonnement non ionisant › Lumière › Preliminary Studies of Antimicrobial Activity...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité microbienne › Preliminary Studies of Antimicrobial Activity...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Preliminary Studies of Antimicrobial Activity...
questionsmedicales.fr › Composés polycycliques › Hydrocarbures aromatiques polycycliques › Phénalènes › Preliminary Studies of Antimicrobial Activity...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Pseudomonadaceae › Pseudomonas › Pseudomonas aeruginosa › Preliminary Studies of Antimicrobial Activity...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Quinoléines › Quinolinone › Preliminary Studies of Antimicrobial Activity...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Preliminary Studies of Antimicrobial Activity...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Imidazoles › Imidazolidines › Hydantoïnes › Thiohydantoïnes › Preliminary Studies of Antimicrobial Activity...