Longitudinal associations between racial discrimination and hippocampal and white matter hyperintensity volumes among older Black adults.
Health disparities
Hippocampus
Stress
White matter hyperintensities
Journal
Social science & medicine (1982)
ISSN: 1873-5347
Titre abrégé: Soc Sci Med
Pays: England
ID NLM: 8303205
Informations de publication
Date de publication:
01 2023
01 2023
Historique:
received:
27
08
2021
revised:
17
01
2022
accepted:
04
02
2022
pmc-release:
01
01
2024
pubmed:
16
2
2022
medline:
11
1
2023
entrez:
15
2
2022
Statut:
ppublish
Résumé
Non-Hispanic Black older adults are at higher risk of Alzheimer's disease and related dementias (ADRD) than non-Hispanic Whites, which reflects racial disparities in both brain and cognitive health. Discrimination may contribute to these disparities, but much of the research on discrimination and ADRD outcomes is cross-sectional and/or does not disaggregate experiences of discrimination by attribution. Focusing specifically on racial discrimination and considering longitudinal brain outcomes may advance our understanding of the role of discrimination in explaining disproportionate rates of ADRD among non-Hispanic Black older adults. In total, 221 non-Hispanic Black participants in the Washington Heights-Inwood Columbia Aging Project completed multiple measures of discrimination at one time point and structural magnetic resonance imaging (MRI) scans at two time points. Everyday discrimination and lifetime discrimination were operationalized first as aggregate experiences of discrimination (regardless of identity attributions) and then as racial discrimination per se. MRI outcomes included hippocampal and white matter hyperintensity (WMH) volumes. Latent difference score models estimated associations between the discrimination measures and each MRI outcome over four years. Aggregate discrimination (regardless of attributions) was not associated with either outcome. Lifetime racial discrimination was associated with lower initial hippocampal volume. Everyday racial discrimination was associated with faster accumulation of WMH over time. Racial discrimination may be detrimental for brain aging among non-Hispanic Black older adults, which may contribute to their disproportionate dementia burden. Disaggregating discrimination by attribution may clarify research on racial inequalities in brain and cognitive aging, as racial discrimination appears to be particularly toxic.
Identifiants
pubmed: 35164975
pii: S0277-9536(22)00095-8
doi: 10.1016/j.socscimed.2022.114789
pmc: PMC9579996
mid: NIHMS1815300
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
114789Subventions
Organisme : NIA NIH HHS
ID : R01 AG054520
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG054023
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG007232
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG037212
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001873
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG072474
Pays : United States
Informations de copyright
Copyright © 2022 Elsevier Ltd. All rights reserved.
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