Synovial inflammation in osteoarthritis progression.
Journal
Nature reviews. Rheumatology
ISSN: 1759-4804
Titre abrégé: Nat Rev Rheumatol
Pays: United States
ID NLM: 101500080
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
accepted:
14
01
2022
pubmed:
16
2
2022
medline:
30
4
2022
entrez:
15
2
2022
Statut:
ppublish
Résumé
Osteoarthritis (OA) is a progressive degenerative disease resulting in joint deterioration. Synovial inflammation is present in the OA joint and has been associated with radiographic and pain progression. Several OA risk factors, including ageing, obesity, trauma and mechanical loading, play a role in OA pathogenesis, likely by modifying synovial biology. In addition, other factors, such as mitochondrial dysfunction, damage-associated molecular patterns, cytokines, metabolites and crystals in the synovium, activate synovial cells and mediate synovial inflammation. An understanding of the activated pathways that are involved in OA-related synovial inflammation could form the basis for the stratification of patients and the development of novel therapeutics. This Review focuses on the biology of the OA synovium, how the cells residing in or recruited to the synovium interact with each other, how they become activated, how they contribute to OA progression and their interplay with other joint structures.
Identifiants
pubmed: 35165404
doi: 10.1038/s41584-022-00749-9
pii: 10.1038/s41584-022-00749-9
pmc: PMC9050956
mid: NIHMS1785158
doi:
Substances chimiques
Cytokines
0
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
258-275Subventions
Organisme : NIAMS NIH HHS
ID : P30 AR073761
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR073324
Pays : United States
Organisme : NIAMS NIH HHS
ID : T32 AR064194
Pays : United States
Organisme : NIAMS NIH HHS
ID : K01 AR077111
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG070647
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR078917
Pays : United States
Informations de copyright
© 2022. Springer Nature Limited.
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