The Pathogenesis and Long-Term Consequences of COVID-19 Cardiac Injury.
CMR, cardiovascular magnetic resonance
COVID-19
COVID-19, coronavirus disease-2019
CT, Computerized Tomography
LGE, late gadolinium enhancement
MI, myocardial infarction
SARS-CoV-2, severe acute respiratory syndrome coronavirus-2
athlete
cardiovascular magnetic resonance imaging
inflammation
myocardial injury
myocarditis
sudden cardiac death
troponin
Journal
JACC. Basic to translational science
ISSN: 2452-302X
Titre abrégé: JACC Basic Transl Sci
Pays: United States
ID NLM: 101677259
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
received:
12
07
2021
revised:
18
10
2021
accepted:
20
10
2021
pubmed:
16
2
2022
medline:
16
2
2022
entrez:
15
2
2022
Statut:
ppublish
Résumé
The mechanisms of coronavirus disease-2019 (COVID-19)-related myocardial injury comprise both direct viral invasion and indirect (hypercoagulability and immune-mediated) cellular injuries. Some patients with COVID-19 cardiac involvement have poor clinical outcomes, with preliminary data suggesting long-term structural and functional changes. These include persistent myocardial fibrosis, edema, and intraventricular thrombi with embolic events, while functionally, the left ventricle is enlarged, with a reduced ejection fraction and new-onset arrhythmias reported in a number of patients. Myocarditis post-COVID-19 vaccination is rare but more common among young male patients. Larger studies, including prospective data from biobanks, will be useful in expanding these early findings and determining their validity.
Identifiants
pubmed: 35165665
doi: 10.1016/j.jacbts.2021.10.011
pii: S2452-302X(21)00318-1
pmc: PMC8828362
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
294-308Informations de copyright
© 2022 The Authors.
Déclaration de conflit d'intérêts
Dr Nazarian has received grants from the National Institutes of Health, ImriCor, Biosense Webster, and ADAS; and is a consultant to CardioSolv and ImroCor. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
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