Imaging of neuroinflammation due to repetitive head injury in currently active kickboxers.
Athletic Injuries
/ diagnostic imaging
Brain
/ metabolism
Craniocerebral Trauma
/ diagnostic imaging
Diffusion Tensor Imaging
Humans
Martial Arts
/ injuries
Neurodegenerative Diseases
/ diagnostic imaging
Neuroinflammatory Diseases
/ diagnostic imaging
Positron-Emission Tomography
/ methods
Receptors, GABA
/ metabolism
Kickboxers
Neuroinflammation
Repetitive head injury
TSPO PET
Journal
European journal of nuclear medicine and molecular imaging
ISSN: 1619-7089
Titre abrégé: Eur J Nucl Med Mol Imaging
Pays: Germany
ID NLM: 101140988
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
received:
28
10
2021
accepted:
28
01
2022
pubmed:
16
2
2022
medline:
8
7
2022
entrez:
15
2
2022
Statut:
ppublish
Résumé
Chronic traumatic encephalopathy refers to a neurodegenerative disease resulting from repetitive head injury of participants in contact sports. Similar to other neurodegenerative diseases, neuroinflammation is thought to play a role in the onset and progression of the disease. Limited knowledge is available regarding the neuroinflammatory consequences of repetitive head injury in currently active contact sports athletes. PET imaging of the 18-kDa translocator protein (TSPO) allows quantification of microglial activation in vivo, a marker of neuroinflammation. Eleven rank A kickboxers and 11 age-matched controls underwent TSPO PET using [ On a group level, no statistically significant differences were detected in non-displaceable binding potential (BP Despite negative results on a group level, individual results suggest that neuroinflammation may be present as a consequence of repetitive head injury in active kickboxers. Future studies using a longitudinal design may determine whether the observed TSPO upregulation is related to the future development of neuropsychiatric symptoms.
Identifiants
pubmed: 35165788
doi: 10.1007/s00259-022-05715-x
pii: 10.1007/s00259-022-05715-x
pmc: PMC9250484
doi:
Substances chimiques
Receptors, GABA
0
TSPO protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3162-3172Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2022. The Author(s).
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