Rapid Screen for Antiviral T-Cell Immunity with Nanowire Electrochemical Biosensors.
SARS-CoV-2
T-cell activation
biosensors
immunoengineering
silicon nanowires
Journal
Advanced materials (Deerfield Beach, Fla.)
ISSN: 1521-4095
Titre abrégé: Adv Mater
Pays: Germany
ID NLM: 9885358
Informations de publication
Date de publication:
Jul 2022
Jul 2022
Historique:
revised:
08
02
2022
received:
27
11
2021
pubmed:
16
2
2022
medline:
23
7
2022
entrez:
15
2
2022
Statut:
ppublish
Résumé
The ability to rapidly assess and monitor patient immune responses is critical for clinical diagnostics, vaccine design, and fundamental investigations into the presence or generation of protective immunity against infectious diseases. Recently, findings on the limits of antibody-based protection provided by B-cells have highlighted the importance of engaging pathogen-specific T-cells for long-lasting and broad protection against viruses and their emergent variants such as in SARS-CoV-2. However, low-cost and point-of-care tools for detecting engagement of T-cell immunity in patients are conspicuously lacking in ongoing efforts to assess and control population-wide disease risk. Currently available tools for human T-cell analysis are time and resource-intensive. Using multichannel silicon-nanowire field-effect transistors compatible with complementary metal-oxide-semiconductor, a device designed for rapid and label-free detection of human T-cell immune responses is developed. The generalizability of this approach is demonstrated by measuring T-cell responses against melanoma antigen MART1, common and seasonal viruses CMV, EBV, flu, as well as emergent pandemic coronavirus, SARS-CoV-2. Further, this device provides a modular and translational platform for optimizing vaccine formulations and combinations, offering quick and quantitative readouts for acquisition and persistence of T-cell immunity against variant-driven pathogens such as flu and pandemic SARS-CoV-2.
Identifiants
pubmed: 35165959
doi: 10.1002/adma.202109661
doi:
Substances chimiques
Antiviral Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2109661Subventions
Organisme : Department of Neurosurgery, Yale Internal Funds
Organisme : Transimmune AG
Organisme : Yale University
Informations de copyright
© 2022 Wiley-VCH GmbH.
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