Discovery of Novel 3-Piperidinyl Pyridine Derivatives as Highly Potent and Selective Cholesterol 24-Hydroxylase (CH24H) Inhibitors.
Animals
Anticholesteremic Agents
/ chemical synthesis
Blood-Brain Barrier
/ metabolism
Brain
/ metabolism
Cholesterol
/ metabolism
Cholesterol 24-Hydroxylase
/ antagonists & inhibitors
Crystallography, X-Ray
Drug Design
Enzyme Inhibitors
/ chemical synthesis
Female
Hydroxycholesterols
Lipids
/ chemistry
Mice
Mice, Inbred C57BL
Pyridines
/ chemical synthesis
Structure-Activity Relationship
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
24 02 2022
24 02 2022
Historique:
pubmed:
16
2
2022
medline:
11
3
2022
entrez:
15
2
2022
Statut:
ppublish
Résumé
Cholesterol 24-hydroxylase (CH24H or CYP46A1) is a brain-specific cytochrome P450 enzyme that metabolizes cholesterol into 24
Identifiants
pubmed: 35166541
doi: 10.1021/acs.jmedchem.1c01898
doi:
Substances chimiques
Anticholesteremic Agents
0
Enzyme Inhibitors
0
Hydroxycholesterols
0
Lipids
0
Pyridines
0
24-hydroxycholesterol
47IMW63S3F
Cholesterol
97C5T2UQ7J
Cholesterol 24-Hydroxylase
EC 1.14.14.25
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM