Nonhuman Primates in Translational Research.
developmental disorders
gene therapy
immune system
in vivo imaging
infectious diseases
preclinical models
Journal
Annual review of animal biosciences
ISSN: 2165-8110
Titre abrégé: Annu Rev Anim Biosci
Pays: United States
ID NLM: 101614024
Informations de publication
Date de publication:
15 02 2022
15 02 2022
Historique:
entrez:
15
2
2022
pubmed:
16
2
2022
medline:
25
2
2022
Statut:
ppublish
Résumé
Nonhuman primates are critically important animal models in which to study complex human diseases, understand biological functions, and address the safety of new diagnostics and therapies proposed for human use. They have genetic, physiologic, immunologic, and developmental similarities when compared to humans and therefore provide important preclinical models of human health and disease. This review highlights select research areas that demonstrate the importance of nonhuman primates in translational research. These include pregnancy and developmental disorders, infectious diseases, gene therapy, somatic cell genome editing, and applications of in vivo imaging. The power of the immune system and our increasing understanding of the role it plays in acute and chronic illnesses are being leveraged to produce new treatments for a range of medical conditions. Given the importance of the human immune system in health and disease, detailed study of the immune system of nonhuman primates is essential to advance preclinical translational research. The need for nonhuman primates continues to remain a high priority, which has been acutely evident during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) global pandemic. Nonhuman primates will continue to address key questions and provide predictive models to identify the safety and efficiency of new diagnostics and therapies for human use across the lifespan.
Identifiants
pubmed: 35167321
doi: 10.1146/annurev-animal-021419-083813
pmc: PMC9339229
mid: NIHMS1822575
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
441-468Subventions
Organisme : NINDS NIH HHS
ID : R21 NS103658
Pays : United States
Organisme : NIH HHS
ID : S10 OD016261
Pays : United States
Organisme : NIH HHS
ID : R21 OD023716
Pays : United States
Organisme : NCRR NIH HHS
ID : S10 RR025063
Pays : United States
Organisme : NIH HHS
ID : S10 OD018102
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI131568
Pays : United States
Organisme : NIBIB NIH HHS
ID : UH2 EB028910
Pays : United States
Organisme : NIH HHS
ID : P51 OD011107
Pays : United States
Organisme : NHLBI NIH HHS
ID : R24 HL085794
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI143554
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS111313
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS109379
Pays : United States
Organisme : NIH HHS
ID : U42 OD027094
Pays : United States
Organisme : NIBIB NIH HHS
ID : UH3 EB028910
Pays : United States
Références
J Acquir Immune Defic Syndr. 2005 Apr 1;38(4):382-92
pubmed: 15764954
Front Immunol. 2019 Sep 12;10:2077
pubmed: 31572355
Cell Host Microbe. 2020 Nov 11;28(5):646-659
pubmed: 33152279
J Immunol. 2017 Jul 15;199(2):806-815
pubmed: 28592427
Chimerism. 2014 Jan-Mar;5(1):6-15
pubmed: 24451553
Vaccines (Basel). 2021 Mar 24;9(4):
pubmed: 33804886
Immunol Today. 1997 Jan;18(1):14-7
pubmed: 9018968
Clin Cancer Res. 2020 Jun 1;26(11):2573-2581
pubmed: 32034075
Cold Spring Harb Perspect Biol. 2018 Apr 2;10(4):
pubmed: 28348034
Science. 2013 May 10;340(6133):711-6
pubmed: 23539181
Elife. 2020 Jun 23;9:
pubmed: 32573433
Hum Gene Ther. 2010 Feb;21(2):143-8
pubmed: 19751148
Mol Ther. 2021 Jun 2;29(6):2019-2029
pubmed: 33609733
Nat Microbiol. 2021 Jan;6(1):73-86
pubmed: 33340034
J Virol. 2006 May;80(10):4858-67
pubmed: 16641277
J Virol. 2004 Jun;78(11):5612-8
pubmed: 15140958
Front Immunol. 2017 Oct 27;8:1407
pubmed: 29163486
Transplantation. 2005 Jan 27;79(2):142-6
pubmed: 15665761
Hum Gene Ther. 2021 Sep;32(17-18):882-894
pubmed: 33406986
Immunology. 1996 Aug;88(4):501-7
pubmed: 8881749
J Immunol. 1999 Mar 15;162(6):3327-35
pubmed: 10092786
Cereb Cortex. 2021 Mar 31;31(5):2309-2321
pubmed: 33341889
Nat Biomed Eng. 2019 May;3(5):371-380
pubmed: 30936432
Sci Adv. 2021 Mar 19;7(12):
pubmed: 33608249
Mol Ther. 2021 Feb 3;29(2):464-488
pubmed: 33309881
Mucosal Immunol. 2011 Mar;4(2):148-57
pubmed: 21228770
Cell. 2020 Jun 25;181(7):1489-1501.e15
pubmed: 32473127
Annu Rev Physiol. 2017 Feb 10;79:619-643
pubmed: 27959620
Hum Gene Ther. 2006 Dec;17(12):1254-61
pubmed: 17134373
Pathobiol Aging Age Relat Dis. 2012;2:
pubmed: 22953039
Alzheimers Dement. 2021 Jun;17(6):933-945
pubmed: 33734581
Hum Gene Ther. 2020 Apr;31(7-8):398-399
pubmed: 32302233
J Neurosci. 2013 Mar 6;33(10):4216-33
pubmed: 23467340
Nat Biotechnol. 2018 Sep;36(8):717-725
pubmed: 29985478
Immunity. 2021 Jun 8;54(6):1276-1289.e6
pubmed: 33836142
Hum Gene Ther Clin Dev. 2015 Sep;26(3):185-93
pubmed: 26390092
Nat Methods. 2015 May;12(5):427-32
pubmed: 25751144
Front Immunol. 2021 Jan 21;11:595297
pubmed: 33552052
J Dev Orig Health Dis. 2019 Jun;10(3):268-273
pubmed: 30466503
Cell. 2020 Nov 25;183(5):1354-1366.e13
pubmed: 33065030
Exp Gerontol. 2014 Jul;55:113-9
pubmed: 24746513
Hum Gene Ther. 2021 Jun;32(11-12):599-615
pubmed: 33860682
Int MS J. 2003 Apr;10(1):6-12
pubmed: 12906764
Infect Immun. 2018 Oct 25;86(11):
pubmed: 30126900
J Immunol. 2004 Mar 1;172(5):2731-8
pubmed: 14978070
Blood Adv. 2020 Dec 22;4(24):6148-6156
pubmed: 33351110
Mol Ther Methods Clin Dev. 2019 Feb 02;13:233-242
pubmed: 30828586
J Anat. 2010 Oct;217(4):276-88
pubmed: 20979582
BMC Genomics. 2008 Apr 17;9:178
pubmed: 18416856
Hum Gene Ther. 2012 Nov;23(11):1130-5
pubmed: 22974119
Science. 1988 Jul 8;241(4862):170-6
pubmed: 3291116
Transl Vis Sci Technol. 2021 Jan 29;10(1):34
pubmed: 33532145
Immunol Rev. 1999 Feb;167:275-304
pubmed: 10319268
Am J Obstet Gynecol. 1976 Mar 15;124(6):647-52
pubmed: 816200
Neuron. 2013 Oct 30;80(3):633-47
pubmed: 24183016
Immunity. 2016 Jun 21;44(6):1379-91
pubmed: 27287409
Lancet. 2018 Feb 10;391(10120):563-571
pubmed: 29217375
Am J Obstet Gynecol. 2015 Oct;213(4 Suppl):S53-69
pubmed: 26428503
Aging Cell. 2021 Jun;20(6):e13374
pubmed: 33951283
J Leukoc Biol. 2019 Nov;106(5):1035-1050
pubmed: 31483523
Blood. 2016 May 19;127(20):2416-26
pubmed: 26980728
Nature. 2010 Mar 25;464(7288):554-561
pubmed: 20154730
Nat Med. 2021 Apr;27(4):632-639
pubmed: 33649496
Age (Dordr). 2012 Oct;34(5):1047-9
pubmed: 22207280
Nature. 2014 Aug 7;512(7512):74-7
pubmed: 25042999
PLoS Pathog. 2020 Sep 18;16(9):e1008903
pubmed: 32946524
PLoS Pathog. 2019 Jan 18;15(1):e1007507
pubmed: 30657788
J Huntingtons Dis. 2020;9(3):201-216
pubmed: 32925082
Nature. 2021 Apr;592(7853):195-204
pubmed: 33828315
Cell Rep Med. 2021 Apr 20;2(4):100247
pubmed: 33948577
Nature. 2021 Feb;590(7847):630-634
pubmed: 33276369
Hum Gene Ther. 2020 Dec;31(23-24):1237-1259
pubmed: 33233962
Mol Ther Methods Clin Dev. 2019 Sep 03;15:133-148
pubmed: 31660416
Mol Ther. 2012 May;20(5):1033-45
pubmed: 22294147
Hum Gene Ther. 2020 Aug;31(15-16):808-818
pubmed: 32845779
Clin Chem. 2021 Jan 30;67(2):351-362
pubmed: 33417673
Exp Gerontol. 2017 Aug;94:41-45
pubmed: 27956088
PLoS One. 2016 Nov 17;11(11):e0166092
pubmed: 27855182
Nat Commun. 2021 Jan 22;12(1):541
pubmed: 33483492
Am J Anat. 1969 Sep;126(1):17-29
pubmed: 4982040
J Immunol. 2011 Aug 15;187(4):1722-32
pubmed: 21765018
J Gerontol A Biol Sci Med Sci. 2005 May;60(5):556-65
pubmed: 15972602
Nature. 2021 Apr;592(7855):616-622
pubmed: 33567448
J Magn Reson Imaging. 2019 Feb;49(2):534-545
pubmed: 30102431
ILAR J. 2017 Dec 1;58(2):281-294
pubmed: 28985318
Blood. 2000 May 1;95(9):2860-8
pubmed: 10779432
J Infect Dis. 1994 May;169(5):1116-20
pubmed: 8169404
Brain Pathol. 2020 Nov;30(6):1017-1027
pubmed: 32585067
Hum Gene Ther Clin Dev. 2017 Mar;28(1):39-50
pubmed: 28319449
Biol Psychiatry. 2021 May 1;89(9):896-910
pubmed: 33386132
Immun Ageing. 2015 May 09;12:3
pubmed: 25991918
Nat Med. 2018 Sep;24(9):1430-1440
pubmed: 30082858
Mucosal Immunol. 2018 May;11(3):932-946
pubmed: 29346349
Nat Commun. 2021 May 17;12(1):2855
pubmed: 34001896
Pediatr Infect Dis J. 2021 May 1;40(5S):S40-S46
pubmed: 34042910
J Nucl Med. 2020 Mar;61(3):453-460
pubmed: 31562219
Science. 2021 Sep 17;373(6561):eabj0299
pubmed: 34529476
Nat Commun. 2016 Dec 20;7:13642
pubmed: 27995928
Biol Reprod. 2001 Dec;65(6):1718-25
pubmed: 11717133
Curr Opin HIV AIDS. 2013 Jul;8(4):255-61
pubmed: 23615116
Hum Gene Ther. 2020 Jul;31(13-14):695-696
pubmed: 32605399
Magn Reson Med. 2019 Mar;81(3):1964-1978
pubmed: 30357902
Nutrients. 2014 Apr 24;6(4):1725-36
pubmed: 24763115
Nature. 2017 Mar 9;543(7644):248-251
pubmed: 28151488
Pediatr Pulmonol. 2016 Oct;51(10):1048-1056
pubmed: 26918397
Biol Reprod. 2008 Sep;79(3):398-406
pubmed: 18495681
Anat Rec (Hoboken). 2013 Nov;296(11):1747-57
pubmed: 23997038
Lancet. 2018 Feb 10;391(10120):552-562
pubmed: 29217376
Nature. 2014 Dec 18;516(7531):418-22
pubmed: 25296253
Science. 2016 Sep 9;353(6304):1129-32
pubmed: 27492477
Neurobiol Dis. 2020 Oct;144:105027
pubmed: 32712266
ILAR J. 2006;47(1):49-64
pubmed: 16391431
Stem Cell Res Ther. 2021 Feb 17;12(1):139
pubmed: 33597015
Exp Neurol. 2018 Jan;299(Pt A):241-251
pubmed: 28698032
Genetics. 2006 Jul;173(3):1555-70
pubmed: 16702430
Sci Transl Med. 2017 Nov 1;9(414):
pubmed: 29093179
Eur J Nucl Med Mol Imaging. 2022 Sep;49(11):3679-3691
pubmed: 35633376
Nat Med. 2017 Sep 8;23(9):1018-1027
pubmed: 28886007
ILAR J. 2012;53(3-4):306-21
pubmed: 23744969
J Virol. 2014 Jun;88(12):6778-92
pubmed: 24696477
J Immunol. 2001 Feb 15;166(4):2420-6
pubmed: 11160301
Andrology. 2021 Sep;9(5):1603-1616
pubmed: 33960147
Nat Med. 2001 Jan;7(1):73-9
pubmed: 11135619
Science. 2020 Aug 14;369(6505):806-811
pubmed: 32434945
Science. 2020 Aug 14;369(6505):812-817
pubmed: 32434946
mBio. 2021 Jan 5;12(1):
pubmed: 33402537
Nature. 2021 May;593(7859):429-434
pubmed: 34012082
J Neurosci. 2016 Feb 03;36(5):1577-89
pubmed: 26843639
Scand J Infect Dis. 2002;34(7):529-33
pubmed: 12195879
J Immunol. 2020 May 15;204(10):2651-2660
pubmed: 32238461
Lab Anim (NY). 2021 May;50(5):113-114
pubmed: 33785923
ILAR J. 2017 Dec 1;58(2):269-280
pubmed: 29216343
J Neuroinflammation. 2020 May 2;17(1):140
pubmed: 32359360
Nat Biotechnol. 2021 Aug;39(8):949-957
pubmed: 34012094
Nat Med. 1999 Apr;5(4):427-30
pubmed: 10202933
Antioxid Redox Signal. 2011 Jan 15;14(2):261-73
pubmed: 20524846
Sci Transl Med. 2019 Jul 31;11(503):
pubmed: 31366580
Nature. 2018 Nov;563(7731):360-364
pubmed: 30283138
Pediatr Res. 2005 Aug;58(2):315-22
pubmed: 16006431
Immun Ageing. 2012 Nov 14;9(1):25
pubmed: 23151307
Am J Physiol Regul Integr Comp Physiol. 2018 May 1;314(5):R684-R692
pubmed: 29412686
Transl Vis Sci Technol. 2021 May 3;10(6):15
pubmed: 34111260
Ann Neurol. 2012 Apr;71(4):444-57
pubmed: 22334391
Immunity. 2019 May 21;50(5):1132-1148
pubmed: 31117010
Anat Rec (Hoboken). 2014 Aug;297(8):1392-406
pubmed: 24867874
Am J Reprod Immunol. 2010 Jun;63(6):587-600
pubmed: 20367625
Dev Neurobiol. 2017 Mar;77(3):263-272
pubmed: 27479140
Lab Anim (NY). 2021 Jun;50(6):140-141
pubmed: 33927412
BMJ Glob Health. 2021 Jun;6(6):
pubmed: 34117012
Nat Rev Immunol. 2018 Jun;18(6):390-404
pubmed: 29556017
Kidney Int. 2001 Feb;59(2):446-56
pubmed: 11168926
Hum Vaccin Immunother. 2019;15(3):625-627
pubmed: 30309284
Cereb Cortex. 2019 Jul 5;29(7):2782-2796
pubmed: 29992243
Front Immunol. 2020 Apr 15;11:494
pubmed: 32351497
Mol Imaging. 2008 Jan-Feb;7(1):1-11
pubmed: 18384718
Anat Rec (Hoboken). 2010 Nov;293(11):1971-83
pubmed: 20818613
Nat Commun. 2020 May 21;11(1):2534
pubmed: 32439858
Mol Imaging Biol. 2012 Apr;14(2):197-204
pubmed: 21479709
Mol Ther. 2019 Sep 4;27(9):1586-1596
pubmed: 31253582
Ernst Schering Res Found Workshop. 2001;(33):145-71
pubmed: 11105259
Am J Pathol. 2010 Feb;176(2):630-7
pubmed: 20035053
Transl Psychiatry. 2019 Apr 12;9(1):135
pubmed: 30979867
Front Microbiol. 2020 May 13;11:882
pubmed: 32477302
Pediatr Allergy Immunol. 2015 Aug;26(5):394-402
pubmed: 26011578
PLoS One. 2013 Oct 03;8(10):e77148
pubmed: 24098579