A prospective cohort study about the effect of repeated living high and working higher on cerebral autoregulation in unacclimatized lowlanders.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
15 02 2022
15 02 2022
Historique:
received:
14
06
2021
accepted:
10
01
2022
entrez:
16
2
2022
pubmed:
17
2
2022
medline:
12
3
2022
Statut:
epublish
Résumé
Cerebral autoregulation (CA) is impaired during acute high-altitude (HA) exposure, however, effects of temporarily living high and working higher on CA require further investigation. In 18 healthy lowlanders (11 women), we hypothesized that the cerebral autoregulation index (ARI) assessed by the percentage change in middle cerebral artery peak blood velocity (Δ%MCAv)/percentage change in mean arterial blood pressure (Δ%MAP) induced by a sit-to-stand maneuver, is (i) reduced on Day1 at 5050 m compared to 520 m, (ii) is improved after 6 days at 5050 m, and (iii) is less impaired during re-exposure to 5050 m after 7 days at 520 m compared to Cycle1. Participants spent 4-8 h/day at 5050 m and slept at 2900 m similar to real-life working shifts. High/low ARI indicate impaired/intact CA, respectively. With the sit-to-stand at 520 m, mean (95% CI) in ΔMAP and ΔMCAv were - 26% (- 41 to - 10) and - 13% (- 19 to - 7), P < 0.001 both comparisons; mean ± SD in ARI was 0.58 ± 2.44Δ%/Δ%, respectively. On Day1 at 5050 m, ARI worsened compared to 520 m (3.29 ± 2.42Δ%/Δ%), P = 0.006 but improved with acclimatization (1.44 ± 2.43Δ%/Δ%, P = 0.039). ARI was less affected during re-exposure to 5050 m (1.22 ± 2.52Δ%/Δ%, P = 0.027 altitude-induced change between sojourns). This study showed that CA (i) is impaired during acute HA exposure, (ii) improves with living high, working higher and (iii) is ameliorated during re-exposure to HA.
Identifiants
pubmed: 35169168
doi: 10.1038/s41598-022-06270-z
pii: 10.1038/s41598-022-06270-z
pmc: PMC8847624
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2472Informations de copyright
© 2022. The Author(s).
Références
Physiol Rep. 2019 Jan;7(2):e13984
pubmed: 30652420
PLoS One. 2014 Mar 21;9(3):e92191
pubmed: 24658407
J Appl Physiol (1985). 2008 Feb;104(2):490-8
pubmed: 18048592
Exp Physiol. 2002 Sep;87(5):633-42
pubmed: 12481938
Neurophotonics. 2016 Jul;3(3):031411
pubmed: 27403447
Respir Physiol Neurobiol. 2007 Sep 30;158(2-3):212-23
pubmed: 17544954
Am J Physiol Heart Circ Physiol. 2017 Jan 1;312(1):H1-H20
pubmed: 27793855
J Cereb Blood Flow Metab. 2011 Jan;31(1):283-92
pubmed: 20571521
J Cereb Blood Flow Metab. 2014 Feb;34(2):248-57
pubmed: 24169852
J Appl Physiol (1985). 2014 Nov 15;117(10):1090-6
pubmed: 25012027
Exp Physiol. 2015 Feb 1;100(2):173-81
pubmed: 25480158
Eur J Appl Physiol. 2020 Mar;120(3):675-686
pubmed: 32034478
J Cereb Blood Flow Metab. 2011 Oct;31(10):2019-29
pubmed: 21654697
J Cereb Blood Flow Metab. 2017 Jun;37(6):2025-2034
pubmed: 27406213
Stroke. 2010 Apr;41(4):641-6
pubmed: 20185774
Aviat Space Environ Med. 1983 Dec;54(12 Pt 1):1063-73
pubmed: 6661120
Med Eng Phys. 2014 Nov;36(11):1487-95
pubmed: 25205587
Front Physiol. 2018 Jun 04;9:677
pubmed: 29915546
Exp Biol Med (Maywood). 2016 Jun;241(12):1351-63
pubmed: 27190276
J Appl Physiol (1985). 2014 Apr 1;116(7):724-9
pubmed: 24371013
J Appl Physiol (1985). 2014 Apr 1;116(7):905-10
pubmed: 23813533
J Appl Physiol (1985). 2010 Mar;108(3):538-43
pubmed: 20056845
Stroke. 2000 Aug;31(8):1897-903
pubmed: 10926954
Front Physiol. 2018 Aug 21;9:1131
pubmed: 30246787
Exp Biol Med (Maywood). 2015 Jul;240(7):961-8
pubmed: 25504012