Macrophage Jak2 deficiency accelerates atherosclerosis through defects in cholesterol efflux.

Animals Atherosclerosis / enzymology Cholesterol / metabolism Janus Kinase 2 / deficiency Macrophages / metabolism Mice Mice, Inbred C57BL

Journal

Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179

Informations de publication

Date de publication:
15 02 2022
Historique:
received: 05 09 2020
accepted: 26 01 2022
entrez: 16 2 2022
pubmed: 17 2 2022
medline: 5 4 2022
Statut: epublish

Résumé

Atherosclerosis is a chronic inflammatory condition in which macrophages play a major role. Janus kinase 2 (JAK2) is a pivotal molecule in inflammatory and metabolic signaling, and Jak2

Identifiants

DOI: 10.1038/s42003-022-03078-5 PMID: 35169231 PMC: PMC8847578
pubmed: 35169231
doi: 10.1038/s42003-022-03078-5
pii: 10.1038/s42003-022-03078-5
pmc: PMC8847578
doi:

Substances chimiques

Cholesterol 97C5T2UQ7J
Jak2 protein, mouse EC 2.7.10.2
Janus Kinase 2 EC 2.7.10.2

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

132

Subventions

Organisme : CIHR
ID : MOP-142193
Pays : Canada
Organisme : CIHR
ID : PJT-159505
Pays : Canada

Informations de copyright

© 2022. The Author(s).

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Auteurs

Idit Dotan (I)

Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.
Institute of Endocrinology, Beilinson Campus, Rabin Medical Center, Petach Tikva, Israel.

Jiaqi Yang (J)

Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.

Jiro Ikeda (J)

Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.

Ziv Roth (Z)

Program in Cell Biology, Peter Gilgan Centre for Research and Learning, Hospital for Sick Children, Toronto, Canada.

Evan Pollock-Tahiri (E)

Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.

Harsh Desai (H)

Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.

Tharini Sivasubramaniyam (T)

Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.

Sonia Rehal (S)

Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.

Josh Rapps (J)

Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.

Yu Zhe Li (YZ)

Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.

Helen Le (H)

Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.

Gedaliah Farber (G)

Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.

Edouard Alchami (E)

Department of Immunology, University of Toronto, Toronto, Canada.

Changting Xiao (C)

Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.
ORCID: 0000-0002-4432-5689

Saraf Karim (S)

Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.

Marcela Gronda (M)

Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.

Michael F Saikali (MF)

Department of Pharmaceutical Sciences, University of Toronto, Toronto, Canada.

Amit Tirosh (A)

Endocrine Cancer Genomics Center, Sheba Medical Center, Tel Hashomer, Israel.

Kay-Uwe Wagner (KU)

Department of Oncology, Wayne State University School of Medicine and Tumor Biology Program, Barbara Ann Karmanos Cancer Institute, Detroit, MI, USA.

Jacques Genest (J)

Research Institute of the McGill University Health Centre, Royal Victoria Hospital, Montreal, QC, Canada.

Aaron D Schimmer (AD)

Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.
ORCID: 0000-0003-4023-3899

Vikas Gupta (V)

Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.

Mark D Minden (MD)

Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.

Carolyn L Cummins (CL)

Department of Pharmaceutical Sciences, University of Toronto, Toronto, Canada.
ORCID: 0000-0001-7603-6577

Gary F Lewis (GF)

Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.

Clinton Robbins (C)

Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.
Department of Immunology, University of Toronto, Toronto, Canada.

Jenny Jongstra-Bilen (J)

Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.
Department of Immunology, University of Toronto, Toronto, Canada.

Myron Cybulsky (M)

Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.
Department of Immunology, University of Toronto, Toronto, Canada.

Minna Woo (M)

Toronto General Hospital Research Institute, University Health Network, Toronto, Canada. mwoo@uhnresearch.ca.
Department of Immunology, University of Toronto, Toronto, Canada. mwoo@uhnresearch.ca.
Division of Endocrinology and Metabolism, Department of Medicine, University Health Network and Sinai Health System, University of Toronto, Toronto, Canada. mwoo@uhnresearch.ca.
ORCID: 0000-0003-2255-1025

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Macrophage Jak2 deficiency accelerates...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Artériopathies oblitérantes › Artériosclérose › Athérosclérose › Macrophage Jak2 deficiency accelerates...
questionsmedicales.fr › Lipides › Lipides membranaires › Stérols › Cholestérol › Macrophage Jak2 deficiency accelerates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Kinase Janus-2 › Macrophage Jak2 deficiency accelerates...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Macrophage Jak2 deficiency accelerates...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Macrophage Jak2 deficiency accelerates...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Macrophage Jak2 deficiency accelerates...